Sesterterpenes from the Tropical Sponge Coscinoderma sp. SCIE SCOPUS

Cited 22 time in WEB OF SCIENCE Cited 25 time in Scopus
Title
Sesterterpenes from the Tropical Sponge Coscinoderma sp.
Author(s)
Bae, Jaemin; Jeon, Ju-eun; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2011-08
Abstract
Eight new sesterterpenes (2, 5, and 10-15), including structurally related pentaprenyl hydroquinones (2 and 5), and seven known ones of the same structural classes were isolated from the sponge Coscinoderma sp., collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lyase, sortase A, and Na(+)/K(+)-ATPase; significant structure activity relationships were evident.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3839
DOI
10.1021/np200492k
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.74, no.8, pp.1805 - 1811, 2011
Publisher
AMER CHEMICAL SOC
Subject
MARINE SPONGE; INHIBITORS; SUVANINE; MATHEWSI; GROWTH; CHEMISTRY; SULFATES; ASSAY
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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