Genotoxicity and Endocrine-Disruption Potentials of Sediment near an Oil Spill Site: Two Years after the Hebei Spirit Oil Spill SCIE SCOPUS

Cited 53 time in WEB OF SCIENCE Cited 54 time in Scopus
Title
Genotoxicity and Endocrine-Disruption Potentials of Sediment near an Oil Spill Site: Two Years after the Hebei Spirit Oil Spill
Author(s)
Ji, Kyunghee; Seo, Jihyeon; Liu, Xiaoshan; Lee, Jinyoung; Lee, Sangwoo; Lee, Woojin; Park, Jeongim; Khim, Jong Seong; Hong, Seongjin; Choi, Yeyong; Shim, Won Joon; Takeda, Shunichi; Giesy, John P.; Choi, Kyungho
KIOST Author(s)
Shim, Won Joon(심원준)
Publication Year
2011-09-01
Abstract
The Hebei Spirit oil spill episode (December 7, 2007) has affected the western coastal area of South Korea; however, there is limited information on the potential toxicity of the oil spill to the ecosystem or humans. The potential toxicity of sediments collected from the affected area (n = 22) 2 years after the spill was evaluated. Acute lethal toxicity tests using Vibrio fischeri and Moina macrocopa and tests for genotoxicity and alteration of steroidogenesis using chicken DT40 cells and H295R cells, respectively, were conducted. Both crude and weathered oil extracts were evaluated in order to link the observed toxicity in the sediment extracts to the oil spill. Whereas toxicity to bacteria and daphnids was observed in only two elutriate samples, 10 of the 22 sediment extracts showed genotoxic potential in DT40 cells. The mechanisms of genotoxicity involved nucleotide excision repair (XPA(-/)), homologous recombination (RAD54(-/-)), and translesion synthesis pathways (REV3(-/-)) In addition, nine sediment extracts caused significantly greater production of E2 in H295R cells, and significant upregulation of CYP19, CYP11B2, and 3 beta HSD2 by sediment extracts was observed. The pattern of toxicities observed in both crude and weathered oil samples was similar to that observed in the sediment extracts. The genotoxicicity and endocrine-disruption potential of the sediment extracts suggest a need for long-term followup for such toxicity in humans and wildlife in this area.
ISSN
0013-936X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3815
DOI
10.1021/es200724x
Bibliographic Citation
ENVIRONMENTAL SCIENCE & TECHNOLOGY, v.45, no.17, pp.7481 - 7488, 2011
Publisher
AMER CHEMICAL SOC
Subject
POLYCYCLIC AROMATIC-HYDROCARBONS; H295R CELLS; TOXICITY; STEROIDOGENESIS; DNA; CONTAMINANTS; EXPOSURE
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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