Cyclic Ether-Containing Macrolactins, Antimicrobial 24-Membered Isomeric Macrolactones from a Marine Bacillus sp.
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Title
- Cyclic Ether-Containing Macrolactins, Antimicrobial 24-Membered Isomeric Macrolactones from a Marine Bacillus sp.
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Author(s)
- Mondol, M. A. Mojid; Tareq, Fakir Shahidullah; Kim, Ji Hye; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Shin, Hee Jae
- KIOST Author(s)
- Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Jong Seok(이종석); Shin, Hee Jae(신희재)
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Alternative Author(s)
- Mondol Md; TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석; 신희재
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Publication Year
- 2011-12
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Abstract
- Bioassay-guided isolation of bioactive metabolites from the ethyl acetate extract of a marine Bacillus sp. fermentation broth has led to the discovery of three new 24-membered macrolactones, macrolactins 1-3, which contain an oxetane, an epoxide, and a tetrahydropyran ring, respectively. The configurations of 1-3 were assigned by a combination of coupling constants, ROESY data analysis, and application of the modified Mosher's method. Compounds 1-3 showed in vitro antimicrobial activity.
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3783
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DOI
- 10.1021/np200487k
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.74, no.12, pp.2582 - 2587, 2011
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Publisher
- AMER CHEMICAL SOC
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Subject
- BACTERIUM; ANTIBACTERIAL; ACID
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Type
- Article
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Language
- English
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Document Type
- Article
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