Synthesis and antimicrobial activity of brominated resorcinol dimers SCIE SCOPUS

Cited 14 time in WEB OF SCIENCE Cited 12 time in Scopus
Title
Synthesis and antimicrobial activity of brominated resorcinol dimers
Author(s)
Bouthenet, Elise; Oh, Ki-Bong; Park, Seungil; Nagi, Navjeet K.; Lee, Hyi-Seung; Matthews, Susan E.
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2011-12-01
Abstract
Dibrominated resorcinol dimers were synthesized by reaction of 4-bromoresorcinol with aldehydes under reflux in ethanol in the presence of HCl. Subsequent dehalogenation yielded the corresponding monobrominated compounds and a fully dehalogenated dimer. Of the dimers, 6,6'-((4-hydroxyphenyl)methylene)bis(4-bromobenzene-1,3-diol) (4) displayed potent antibacterial activity and inhibitory activity against isocitrate lyase Candida albicans. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3779
DOI
10.1016/j.bmcl.2011.09.072
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.23, pp.7142 - 7145, 2011
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ALGA SYMPHYOCLADIA-LATIUSCULA; ISOCITRATE LYASE INHIBITORS; RED ALGA; ODONTHALIA-CORYMBIFERA; RHODOMELA-CONFERVOIDES; CANDIDA-ALBICANS; LIVING CELLS; BROMOPHENOLS; CONDENSATION; 2,4-DIHYDROXYDIPHENYLMETHANE
Keywords
Bromophenol; Red alga; Antibacterial activity; Antifungal activity; Resorcinol
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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