Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Seo, Jong Bae | - |
dc.contributor.author | Park, Sang Wook | - |
dc.contributor.author | Choe, Sung Sik | - |
dc.contributor.author | Jeong, Hyun Woo | - |
dc.contributor.author | Park, Jae Young | - |
dc.contributor.author | Choi, Eun-Wook | - |
dc.contributor.author | Seen, Dong-Seung | - |
dc.contributor.author | Jeong, Jae-Yeon | - |
dc.contributor.author | Lee, Tae Gyu | - |
dc.date.accessioned | 2020-04-20T06:55:44Z | - |
dc.date.available | 2020-04-20T06:55:44Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2012-01-13 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3645 | - |
dc.description.abstract | We have previously reported anti-obesity effects of Lysimachia foenum-graecum in high-fat diet (HFD)-induced obesity model. Here we isolated a triterpene saponin foenumoside B as an active component of L. foenum-graecum. Foenumoside B blocked the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner with an IC50 of 0.2 mu g/ml in adipogenesis assay and suppressed the induction of PPAR gamma, the master regulator of adipogenesis. Foenumoside B induced the activation of AMP-activated protein kinase (AMPK), and modulated the expression of genes involved in lipid metabolism towards lipid breakdown in differentiated adipocytes. In mouse model, oral administration of foenumoside B (10 mg/kg/day for 6 weeks) reduced HFD-induced body weight gain significantly without affecting food intake. Treatment of foenumoside B suppressed lipid accumulation in white adipose tissues and the liver, and lowered blood levels of glucose, triglycerides, ALT, and AST in HFD-induced obese mice. Consistent with the in vitro results, foenumoside B activated AMPK signaling, suppressed the expression of lipogenic genes, and enhanced the expression of lipolytic genes in vivo. Foenumoside B also blocked HFD-induced proinflammatory cytokine production in adipose tissue, suggesting its protective role against insulin resistance. Taken together, these findings demonstrate that foenumoside B represents the anti-obesity effects of L. foenum-graecum, and suggest therapeutic potential of foenumoside B in obesity and obesity-related metabolic diseases. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ACTIVATED PROTEIN-KINASE | - |
dc.subject | LIVER-DISEASE | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | EXPRESSION | - |
dc.subject | ALPHA | - |
dc.subject | CANCER | - |
dc.subject | GAMMA | - |
dc.subject | MICE | - |
dc.subject | AMPK | - |
dc.title | Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet | - |
dc.type | Article | - |
dc.citation.endPage | 806 | - |
dc.citation.startPage | 800 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 417 | - |
dc.citation.number | 2 | - |
dc.contributor.alternativeName | 정재연 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.417, no.2, pp.800 - 806 | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.12.039 | - |
dc.identifier.scopusid | 2-s2.0-84855855566 | - |
dc.identifier.wosid | 000299610200026 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Foenumoside B | - |
dc.subject.keywordAuthor | Lysimachia foenum-graecum | - |
dc.subject.keywordAuthor | High-fat diet | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |