Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet SCIE SCOPUS

Cited 19 time in WEB OF SCIENCE Cited 23 time in Scopus
Title
Foenumoside B from Lysimachia foenum-graecum inhibits adipocyte differentiation and obesity induced by high-fat diet
Author(s)
Seo, Jong Bae; Park, Sang Wook; Choe, Sung Sik; Jeong, Hyun Woo; Park, Jae Young; Choi, Eun-Wook; Seen, Dong-Seung; Jeong, Jae-Yeon; Lee, Tae Gyu
Publication Year
2012-01-13
Abstract
We have previously reported anti-obesity effects of Lysimachia foenum-graecum in high-fat diet (HFD)-induced obesity model. Here we isolated a triterpene saponin foenumoside B as an active component of L. foenum-graecum. Foenumoside B blocked the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner with an IC50 of 0.2 mu g/ml in adipogenesis assay and suppressed the induction of PPAR gamma, the master regulator of adipogenesis. Foenumoside B induced the activation of AMP-activated protein kinase (AMPK), and modulated the expression of genes involved in lipid metabolism towards lipid breakdown in differentiated adipocytes. In mouse model, oral administration of foenumoside B (10 mg/kg/day for 6 weeks) reduced HFD-induced body weight gain significantly without affecting food intake. Treatment of foenumoside B suppressed lipid accumulation in white adipose tissues and the liver, and lowered blood levels of glucose, triglycerides, ALT, and AST in HFD-induced obese mice. Consistent with the in vitro results, foenumoside B activated AMPK signaling, suppressed the expression of lipogenic genes, and enhanced the expression of lipolytic genes in vivo. Foenumoside B also blocked HFD-induced proinflammatory cytokine production in adipose tissue, suggesting its protective role against insulin resistance. Taken together, these findings demonstrate that foenumoside B represents the anti-obesity effects of L. foenum-graecum, and suggest therapeutic potential of foenumoside B in obesity and obesity-related metabolic diseases. (C) 2011 Elsevier Inc. All rights reserved.
ISSN
0006-291X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3645
DOI
10.1016/j.bbrc.2011.12.039
Bibliographic Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.417, no.2, pp.800 - 806, 2012
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Subject
ACTIVATED PROTEIN-KINASE; LIVER-DISEASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; EXPRESSION; ALPHA; CANCER; GAMMA; MICE; AMPK
Keywords
Obesity; Foenumoside B; Lysimachia foenum-graecum; High-fat diet; AMPK; PPAR gamma
Type
Article
Language
English
Document Type
Article
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
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