IN VITRO ANTIOXIDANT ACTIVITIES OF THE FERMENTED MARINE MICROALGA PAVLOVA LUTHERI (HAPTOPHYTA) WITH THE YEAST HANSENULA POLYMORPHA
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Title
- IN VITRO ANTIOXIDANT ACTIVITIES OF THE FERMENTED MARINE MICROALGA PAVLOVA LUTHERI (HAPTOPHYTA) WITH THE YEAST HANSENULA POLYMORPHA
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Author(s)
- Qian, Zhong-Ji; Jung, Won-Kyo; Kang, Kyong-Hwa; Ryu, BoMi; Kim, Se-Kwon; Je, Jae-Young; Heo, Soo-Jin; Oh, Chulhong; Kang, Do-Hyung; Park, Won Sun; Choi, Il-Whan
- KIOST Author(s)
- Heo, Soo Jin(허수진); Oh, Chul Hong(오철홍); Kang, Do Hyung(강도형)
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Alternative Author(s)
- 허수진; 오철홍; 강도형
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Publication Year
- 2012-04
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Abstract
- Microalgae are major primary producers of organic matter in aquatic environments through their photosynthetic activities. Fermented microalga (Pavlova lutheri Butcher) preparation (FMP) is the product of yeast fermentation by Hansenula polymorpha. It was tested for the antioxidant activities including lipid peroxidation inhibitory activity, free-radical-scavenging activity, inhibition of reactive oxygen species (ROS) on mouse macrophages (RAW264.7 cell), and inhibited myeloperoxidase (MPO) activity in human myeloid cells (HL60). FMP exhibited the highest antioxidant activity on free-radical scavenging, inhibitory intracellular ROS, and inhibited MPO activity. MTT [3-(4,5-dimethyl-2-yl)-2,5-diphenyltetrazolium bromide] assay showed no cytotoxicity in mouse macrophages (RAW264.7 cell), human myeloid cells (HL60), and human fetal lung fibroblast cell line (MRC-5). Furthermore, the antioxidative mechanism of FMP was evaluated by protein expression levels of antioxidant enzyme (superoxide dismutase [SOD] and glutathione [GSH]) using Western blot. The results obtained in the present study indicated that FMP is a potential source of natural antioxidant.
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ISSN
- 0022-3646
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3607
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DOI
- 10.1111/j.1529-8817.2012.01117.x
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Bibliographic Citation
- JOURNAL OF PHYCOLOGY, v.48, no.2, pp.475 - 482, 2012
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Publisher
- WILEY-BLACKWELL
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Subject
- TEA CATECHINS; ACID; SUPEROXIDE; GROWTH
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Keywords
- antioxidant activities; fermented; Hansenula polymorpha; marine microalgae; Pavlova lutheri
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Type
- Article
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Language
- English
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Document Type
- Article
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