IN VITRO ANTIOXIDANT ACTIVITIES OF THE FERMENTED MARINE MICROALGA PAVLOVA LUTHERI (HAPTOPHYTA) WITH THE YEAST HANSENULA POLYMORPHA SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 7 time in Scopus
Title
IN VITRO ANTIOXIDANT ACTIVITIES OF THE FERMENTED MARINE MICROALGA PAVLOVA LUTHERI (HAPTOPHYTA) WITH THE YEAST HANSENULA POLYMORPHA
Author(s)
Qian, Zhong-Ji; Jung, Won-Kyo; Kang, Kyong-Hwa; Ryu, BoMi; Kim, Se-Kwon; Je, Jae-Young; Heo, Soo-Jin; Oh, Chulhong; Kang, Do-Hyung; Park, Won Sun; Choi, Il-Whan
KIOST Author(s)
Heo, Soo Jin(허수진)Oh, Chul Hong(오철홍)Kang, Do Hyung(강도형)
Publication Year
2012-04
Abstract
Microalgae are major primary producers of organic matter in aquatic environments through their photosynthetic activities. Fermented microalga (Pavlova lutheri Butcher) preparation (FMP) is the product of yeast fermentation by Hansenula polymorpha. It was tested for the antioxidant activities including lipid peroxidation inhibitory activity, free-radical-scavenging activity, inhibition of reactive oxygen species (ROS) on mouse macrophages (RAW264.7 cell), and inhibited myeloperoxidase (MPO) activity in human myeloid cells (HL60). FMP exhibited the highest antioxidant activity on free-radical scavenging, inhibitory intracellular ROS, and inhibited MPO activity. MTT [3-(4,5-dimethyl-2-yl)-2,5-diphenyltetrazolium bromide] assay showed no cytotoxicity in mouse macrophages (RAW264.7 cell), human myeloid cells (HL60), and human fetal lung fibroblast cell line (MRC-5). Furthermore, the antioxidative mechanism of FMP was evaluated by protein expression levels of antioxidant enzyme (superoxide dismutase [SOD] and glutathione [GSH]) using Western blot. The results obtained in the present study indicated that FMP is a potential source of natural antioxidant.
ISSN
0022-3646
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3607
DOI
10.1111/j.1529-8817.2012.01117.x
Bibliographic Citation
JOURNAL OF PHYCOLOGY, v.48, no.2, pp.475 - 482, 2012
Publisher
WILEY-BLACKWELL
Subject
TEA CATECHINS; ACID; SUPEROXIDE; GROWTH
Keywords
antioxidant activities; fermented; Hansenula polymorpha; marine microalgae; Pavlova lutheri
Type
Article
Language
English
Document Type
Article
Publisher
WILEY-BLACKWELL
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