Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells SCIE SCOPUS

Cited 48 time in WEB OF SCIENCE Cited 44 time in Scopus
Title
Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells
Author(s)
Kang, Sung-Myung; Cha, Seon-Heui; Ko, Ju-Young; Kang, Min-Cheol; Kim, Daekyung; Heo, Soo-Jin; Kim, Jin-Soo; Heu, Min Soo; Kim, Yong-Tae; Jung, Won-Kyo; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2012-07
Abstract
Exposure of neurons to hydrogen peroxide (H2O2) results in oxidative stress and the activation of a cascade of intracellular toxic events resulting in oxidation, lipid peroxidation, and Ca2+ elevation, ultimately resulting in cell death. In this study, we attempted to characterize the neuroprotective effects of phlorotannins isolated from Ecklonia cam, including phloroglucinol, eckol, triphloroethol A, eckstolonol, and dieckol, against H2O2-induced cell damage in murine hippocampus neuronal (HT22) cells. We measured the reactive oxygen species (ROS) and lipid peroxidation levels and evaluated the resultant cell death and alterations in Ca2+-concentrations. All phlorotannins were to scavenge intracellular ROS and repress ROS accumulation, thus preventing lipid peroxidation. Consquently, all phlorotannins reduced H2O2-induced cell death in HT22 cells. Moreover, phlorotannins inhibited H2O2-induced Ca2+. release. This study provides a new useful strategy for preventing neuronal H2O2-induced oxidative stress. (C) 2012 Elsevier B.V. All rights reserved.
ISSN
1382-6689
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3497
DOI
10.1016/j.etap.2012.03.006
Bibliographic Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.34, no.1, pp.96 - 105, 2012
Publisher
ELSEVIER SCIENCE BV
Subject
NF-KAPPA-B; HYDROGEN-PEROXIDE; LUNG FIBROBLAST; DEATH; ACTIVATION; APOPTOSIS; DAMAGE; MICROGLIA; TOXICITY; PATHWAYS
Keywords
Neuroprotection; Ecklonia cava; Phlorotannin; Oxidative stress
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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