Centrodinium punctatum (Dinophyceae) produces significant levels of saxitoxin and related analogs

Title
Centrodinium punctatum (Dinophyceae) produces significant levels of saxitoxin and related analogs
Author(s)
Shin, Hyeon Ho; Li, Zhun; Damien Réveillon; Georges-Augustin Rovillon; Kenneth Neil Mertens; Philipp Hess; Kim, Hyunjung; Lee, Jihoon; Lee, Kyun Woo; Lee, Yeon Ju; Park, Bum Soo
KIOST Author(s)
Shin, Hyeon Ho(신현호)Kim, Hyunjung(김현정)Lee, Jihoon(이지훈)Lee, Kyun Woo(이균우)Lee, Yeon Ju(이연주)Park, Bum Soo(박범수)
Publication Year
2020-07-22
Abstract
Centrodinium punctatum is a fusiform dinoflagellate with a global marine distribution. Due to its close relation with Alexandrium species, toxin production was assessed through analysis of culture of one strain from the East China Sea using liquid chromatography coupled to tandem mass spectrometry. The paralytic shellfish toxin (PST) in the strain of C. punctatum was dominated by six analogs, i.e. STX (30%), GTX-1 (20%) and neoSTX (24%), followed by GTX2 (9%), GTX-4 (9%) and GTX3 (8%); deoxy-STX was also putatively identified while no gymnodimines, spirolides or goniodomins were detected. This is the first record of C. punctatum producing saxitoxins. The estimated cellular toxicity was rather elevated, between 91 and 212 pg cell-1 (or 259 and 601 fmol cell-1). When considering the toxicity equivalent factors, results suggest that this species can produce high cellular toxicity compared to other STX-producing dinoflagellates. In addition, morphological details of the sulcal area and the hypotheca of this species were re-examined by scanning electron microscopy (SEM). SEM revealed that in the sulcal area, the left posterior sulcal plate (Ssp) is larger and longer than the left posterior sulcal plate and extended into the hypotheca. A revised interpretation of the sulcus and hypotheca is proposed.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/33130
Bibliographic Citation
2020년도 한국해양과학기술협의회 공동학술대회 (한국해양학회), 2020
Publisher
한국해양과학기술협의회
Type
Conference
Language
Korean
Publisher
한국해양과학기술협의회
Related Researcher
Research Interests

organic chemistry,natural product chemistry,유기화학,천연물화학

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