BEMP-Promoted C(4)-Alkylation of 4-Alkyloxazol-5(4H)-ones: A Rapid and Efficient Route to alpha,alpha-Dialkyl-alpha-amino Acids SCIE SCOPUS
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Yeon-Ju | - |
| dc.contributor.author | Seo, Jeyoung | - |
| dc.contributor.author | Kim, Dong-Guk | - |
| dc.contributor.author | Park, Hyeung-geun | - |
| dc.contributor.author | Jeong, Byeong-Seon | - |
| dc.date.accessioned | 2020-04-20T05:52:08Z | - |
| dc.date.available | 2020-04-20T05:52:08Z | - |
| dc.date.created | 2020-01-28 | - |
| dc.date.issued | 2013-04 | - |
| dc.identifier.issn | 0936-5214 | - |
| dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/3205 | - |
| dc.description.abstract | Rapid and efficient C(4)-alkylation of 4-alkyloxazol-5(4H)-ones has been achieved by the utilization of BEMP as base. 4,4-Dialkyloxazol-5(4H)-ones, which can easily be hydrolyzed into free alpha,alpha-dialkyl-alpha-amino acids, were obtained in high yields (up to 99%) within a few minutes (1-18 min). BEMP, a sterically hindered strong base with low nucleophilicity facilitated the desired reaction, while decreasing the rate of side reactions such as O-alkylation, C(2)-alkylation and the breakage of oxazolone. | - |
| dc.description.uri | 1 | - |
| dc.language | English | - |
| dc.publisher | GEORG THIEME VERLAG KG | - |
| dc.subject | ALPHA-AMINO-ACIDS | - |
| dc.subject | ASYMMETRIC-SYNTHESIS | - |
| dc.subject | STEREOSELECTIVE-SYNTHESIS | - |
| dc.subject | AZLACTONES | - |
| dc.subject | ALKYLATION | - |
| dc.subject | CONFORMATION | - |
| dc.subject | CATALYST | - |
| dc.subject | DESIGN | - |
| dc.subject | OXAZOL-5-(4H)-ONES | - |
| dc.subject | ORGANOCATALYSTS | - |
| dc.title | BEMP-Promoted C(4)-Alkylation of 4-Alkyloxazol-5(4H)-ones: A Rapid and Efficient Route to alpha,alpha-Dialkyl-alpha-amino Acids | - |
| dc.type | Article | - |
| dc.citation.endPage | 704 | - |
| dc.citation.startPage | 701 | - |
| dc.citation.title | SYNLETT | - |
| dc.citation.volume | 24 | - |
| dc.citation.number | 6 | - |
| dc.contributor.alternativeName | 이연주 | - |
| dc.identifier.bibliographicCitation | SYNLETT, v.24, no.6, pp.701 - 704 | - |
| dc.identifier.doi | 10.1055/s-0032-1317801 | - |
| dc.identifier.scopusid | 2-s2.0-84874608430 | - |
| dc.identifier.wosid | 000317956600005 | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | ALPHA-AMINO-ACIDS | - |
| dc.subject.keywordPlus | ASYMMETRIC-SYNTHESIS | - |
| dc.subject.keywordPlus | STEREOSELECTIVE-SYNTHESIS | - |
| dc.subject.keywordPlus | AZLACTONES | - |
| dc.subject.keywordPlus | ALKYLATION | - |
| dc.subject.keywordPlus | CONFORMATION | - |
| dc.subject.keywordPlus | CATALYST | - |
| dc.subject.keywordPlus | DESIGN | - |
| dc.subject.keywordPlus | OXAZOL-5-(4H)-ONES | - |
| dc.subject.keywordPlus | ORGANOCATALYSTS | - |
| dc.subject.keywordAuthor | alpha,alpha-dialkyl-alpha-amino acid | - |
| dc.subject.keywordAuthor | oxazol-5(4H)-one | - |
| dc.subject.keywordAuthor | C(4)-alkylation | - |
| dc.subject.keywordAuthor | BEMP | - |
| dc.subject.keywordAuthor | protecting group | - |
| dc.subject.keywordAuthor | chemoselectivity | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
- Appears in Collections:
- Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 1. Journal Articles
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