Two molluscan BCL-2 family members from Manila clam, Ruditapes philippinarum: Molecular characterization and immune responses
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Title
- Two molluscan BCL-2 family members from Manila clam, Ruditapes philippinarum: Molecular characterization and immune responses
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Author(s)
- Lee, Youngdeuk; Whang, Ilson; Lee, Sukkyoung; Menike, Udeni; Oh, Chulhong; Kang, Do-Hyung; Heo, Gang-Joon; Lee, Jehee; De Zoysa, Mahanama
- KIOST Author(s)
- Lee, Young Deuk(이영득); Oh, Chul Hong(오철홍); Kang, Do Hyung(강도형)
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Alternative Author(s)
- 이영득; 오철홍; 강도형
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Publication Year
- 2013-06
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Abstract
- Apoptosis based immune responses are important component of host defense in mollusks. In this study, we have identified two novel molluscan BCL-2 cDNAs from Manila clam, Ruditapes philippinarum and named as RpBCL-2A and RpBCL-2B. There were four and three highly conserved BCL-2 homology (BH) regions in RpBCL-2A and RpBCL-2B, respectively suggesting these two genes could be different isoforms of anti-apoptotic BCL-2 family. Phylogenetic results revealed that Manila clam BCL-2 genes were clustered closely with invertebrate BCL-2 members. It gives evidence of their common origin and conserved features of invertebrate BCL-2 family. RpBCL-2A and 2B were expressed in tissue-specific manner showing the highest and lowest level of expression in gills and hemocytes, respectively. However there was no clear expression profile difference between two genes. After Vibrio tapetis challenge, transcriptional responses of RpBCL-2A and RpBCL-2B were induced in gills and hemocytes with high variation that could be due to effects of immune reactions of other host defense molecules. (C) 2013 Elsevier Ltd. All rights reserved.
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ISSN
- 1050-4648
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3186
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DOI
- 10.1016/j.fsi.2013.03.366
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Bibliographic Citation
- FISH & SHELLFISH IMMUNOLOGY, v.34, no.6, pp.1628 - 1634, 2013
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Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
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Subject
- MITOCHONDRIAL PATHWAY; APOPTOSIS; DEATH; EXPRESSION; STRESS; COMPLEXITY; EVOLUTION; ALIGNMENT; LIFE
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Keywords
- Apoptosis; B cell lymphoma 2 (BCL-2); Manila clam; Ruditapes philippinarum; Vibrio tapetis
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Type
- Article
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Language
- English
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Document Type
- Article
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