Cytotoxic Psammaplysin Analogues from a Suberea sp. Marine Sponge and the Role of the Spirooxepinisoxazoline in Their Activity SCIE SCOPUS

Cited 23 time in WEB OF SCIENCE Cited 23 time in Scopus
Title
Cytotoxic Psammaplysin Analogues from a Suberea sp. Marine Sponge and the Role of the Spirooxepinisoxazoline in Their Activity
Author(s)
Lee, Yeon-Ju; Han, Saem; Lee, Hyi-Seung; Kang, Jong Soon; Yun, Jieun; Sim, Chung J.; Shin, Hee Jae; Lee, Jong Seok
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)Shin, Hee Jae(신희재)Lee, Jong Seok(이종석)
Alternative Author(s)
이연주; 한샘; 이희승; 신희재; 이종석
Publication Year
2013-09
Abstract
Seventeen bromotyrosine-derived metabolites, including eight new compounds, were isolated from a Micronesian sponge of the genus Suberea. Four of the new compounds were psammaplysin derivatives (10-13), and the other four were ceratinamine derivatives (14-17). Of the compounds obtained, the psammaplysins exhibited cytotoxicity against human cancer cell lines (GI(50) values down to 0.8 mu M), while the ceratinamine and moloka'iamine analogues showed almost no activity. These results suggest that the spirooxepinisoxazoline ring system is a requirement for cytotoxicity and, therefore, may serve as an attractive molecular scaffold for the development of a potent anticancer agent.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/3118
DOI
10.1021/np400448y
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.76, no.9, pp.1731 - 1736, 2013
Publisher
AMER CHEMICAL SOC
Subject
BROMOTYROSINE DERIVATIVES; PSEUDOCERATINA PURPUREA; APLYSINELLA SP; METABOLITES; CYANOFORMAMIDE; ALKALOIDS
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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