Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models
SCIE
SCOPUS
Cited 9 time in
WEB OF SCIENCE
Cited 29 time in
Scopus
-
Title
- Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models
-
Author(s)
- Lee, Seung-Hwan; Shin, Hee Jae; Kim, Dong-Young; Shim, Do-Wan; Kim, Tack-Joong; Ye, Sang-Kyu; Won, Hyung-Sik; Koppula, Sushruta; Kang, Tae-Bong; Lee, Kwang-Ho
- KIOST Author(s)
- Shin, Hee Jae(신희재)
-
Alternative Author(s)
- 신희재
-
Publication Year
- 2013-09-27
-
Abstract
- Allergic diseases are chronic inflammatory conditions with specific immune and inflammatory mechanisms. Scientific interest in understanding the mechanisms and discovering novel agents for the prevention and treatment of allergic disease is increasing. Streptochlorin, a small compound derived from marine actinomycete possesses anti-angiogenic and anti-tumor activities. However, the anti-allergic effects and underlying mechanisms remain to be elucidated. In the present study, we investigated the effect of streptochlorin on allergic responses in vitro and in vivo. Streptochlorin inhibited degranulation and production of tumor necrosis factor-alpha and IL-4 by antigen-stimulated mast cells. Streptochlorin also inhibited the phosphorylation of Akt and the mitogen-activated protein kinases (MAPKs), including p38, ERK, and JNK. Further, streptochlorin reduced the phosphorylation of Syk in RBL-2H3 cells and inhibited the activity of Lyn and Fyn. Furthermore, administration of streptochlorin suppressed the allergic reactions in both passive cutaneous anaphylaxis reaction and 2, 4-dinitrofluorobenzene (DNFB)-induced allergic dermatitis in mice model. Considering the data obtained, we report for the first time that streptochlorin possess anti-allergic properties. The underlying mechanism of streptochlorin in exhibiting potent anti-allergic activity might be through the inhibition of the Lyn/Fyn and Syk signaling pathways.
-
ISSN
- 1932-6203
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/3095
-
DOI
- 10.1371/journal.pone.0074194
-
Bibliographic Citation
- PLOS ONE, v.8, no.9, 2013
-
Publisher
- PUBLIC LIBRARY SCIENCE
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.