해양방선균에서 분리된 신생혈관억제 및 항암활성을 가지는 화합물

Abstract

Angiogenesis is the formation of new capillary blood vessels from existent myicro vessels and also involves differential recruitment of associated supporting cells to different segments of the cvasculature. Because tumor angiogenesis caused by angiogenic inducers is the most critical factor in the growth of solid tumors, as well as their invasion and metastasis, early control of angiogenesis may be a promising therapeutic stratedy for the related diseases. As part of our ongoing program to develop the biomedical potential of marine microorganisms, we have focused considerable attention on the marine actinomycetes. From the bioactive isolates several new actinomycetes have been identified and a variety of bioactive molecules were characterized. We present here the discovery of anti-angiogenesis and cytotoxic compounds from marine-derived actinomycetes. The isolation, structure determination, and anticancer activity of the compounds from marine actinomycetes will be presented.