Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors SCIE SCOPUS

DC Field Value Language Hwang, Jong Yeon - Kim, Hee-Young - Jo, Suyeon - Park, Eunjung - Choi, Jihyun - Kong, Sunju - Park, Dong-Sik - Heo, Ja Myung - Lee, Jong Seok - Ko, Yoonae - Choi, Inhee - Cechetto, Jonathan - Kim, Jaeseung - Lee, Jinhwa - No, Zaesung - Windisch, Marc Peter - 2020-04-20T05:25:14Z - 2020-04-20T05:25:14Z - 2020-02-04 - 2013-12 -
dc.identifier.issn 0223-5234 -
dc.identifier.uri -
dc.description.abstract In order to identify novel anti-hepatitis C virus (HCV) agents we devised cell-based strategies and screened phenotypically small molecule chemical libraries with infectious HCV particles, and identified a hit compound (1) containing a hexahydropyrimidine (HHP) core. During our cell-based SAR study, we observed a conversion of HHP 1 into a linear diamine (6), which is the active component in inhibiting HCV and exhibited comparable antiviral activity to the cyclic HHP I. In addition, we engaged into the biological characterization of HHP and demonstrated that HHP does not interfere with HCV RNA replication, but with entry and release of viral particles. Here we report the results of the preliminary SAR and mechanism of action studies with HHP. (C) 2013 Elsevier Masson SAS. All rights reserved. -
dc.description.uri 1 -
dc.language English -
dc.subject DERIVATIVES -
dc.subject DISCOVERY -
dc.title Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors -
dc.type Article -
dc.citation.endPage 325 -
dc.citation.startPage 315 -
dc.citation.volume 70 -
dc.contributor.alternativeName 이종석 -
dc.identifier.bibliographicCitation EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.70, pp.315 - 325 -
dc.identifier.doi 10.1016/j.ejmech.2013.09.055 -
dc.identifier.wosid 000330554400027 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus DERIVATIVES -
dc.subject.keywordPlus DISCOVERY -
dc.subject.keywordAuthor Hepatitis C virus -
dc.subject.keywordAuthor Phenotypic screening -
dc.subject.keywordAuthor Hexahydropyrimidine -
dc.subject.keywordAuthor Diamines -
dc.subject.keywordAuthor Entry -
dc.subject.keywordAuthor Release -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
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Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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