Marine Microorganisms As a Source for the Discovery of Bioactive Molecules

Title
Marine Microorganisms As a Source for the Discovery of Bioactive Molecules
Author(s)
신희재
KIOST Author(s)
Shin, Hee Jae(신희재)
Publication Year
2008-05-22
Abstract
Natural products remain either the source of or the inspiration for a significant proportion of the new small-molecule chemical entities introduced as drugs. Although marine plants and invertebrates have received considerable attention as a resource for natural product discovery, the bioactive compounds of marine microorganisms remain relatively unexplored.To search for new bioactive marine natural products, we have isolated more than 4,000 strains of marine-derived actinomycetes from the various marine samples such as deep sea and shallow water sediments, marine seaweed and invertebrates. We also have established that about 10% of isolates show some bioactivity in our assays such as cytotoxicity, anti-angiogenic, antimicrobial, antifungal, and enzyme inhibitory activities. From the active strains, we could isolate many bioactive compounds such as cytotoxic compounds, angiogenesis inhibitors and antimicrobial compounds. We present here the discovery of angiogenesis inhibitors and cytotoxic compounds from marine-derived actinomycetes. The isolation, structure determination, and biological activities of the secondary metabolites from marine actinomycetes will be the focus of this presentation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/30025
Bibliographic Citation
The 4th Korea-Japan Chemical Biology Symposium, pp.6, 2008
Publisher
Organizing Committee of the 4th Korea-Japan Chemical Biology Symposium
Type
Conference
Language
English
Publisher
Organizing Committee of the 4th Korea-Japan Chemical Biology Symposium
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