1-Acetyl-ß-carboline compound isolated from a marine actinomycete strain 04DH211

Abstract

Recently, marine organisms are a recognized source of novel metabolites with valuable biological properties and molecular diversity. Marine organisms have evolved with unique metabolic and physiological capabilities to adapt themselves to extreme habitats. They produce the potent bioactive compounds that would not be observed from terrestrial microorganisms. From the fact that actinomycetes isolated from marine organisms are promising sources for secondary metabolites such as antibiotic substances. Thus, we have focused our exploration on the isolation, structural elucidation of bioactive compounds from marine microorganisms. In the course of our continuing search for new anticancer materials from marine derived actinomycetes, eudistomin class compound was isolated from the culture broth of strain 04DH211. The structure of this compound, which possess significant antibiotic properties, cancer cell cytotoxicities, antifungal, antibacterial in vitro bioassays, was assigned by spectral measurements and comparison with extensive MS, UV and NMR spectral analyses. In this paper we describe the isolation, structure elucidation of this compound.