Thermococcus onnurineus NA1의 유전체분석 연구

Title
Thermococcus onnurineus NA1의 유전체분석 연구
Alternative Title
The Complete Genome Sequence of Thermococcus onnurineus NA1 Reveals a Mixed Heterotrophic and Carboxydotrophic Metabolism
Author(s)
강성균; 이현숙; 배승섭; 김윤재; 김상진; 이정현
KIOST Author(s)
Kang, Sung Gyun(강성균)Lee, Hyun Sook(이현숙)Lee, Jung Hyun(이정현)
Publication Year
2008-09-01
Abstract
Members of the genus Thermococcus, sulfur-reducing hyperthermophilic archaea, are ubiquitously present in various deep-sea hydrothermal vent systems and are considered to play a significant role in the microbial consortia. We present the complete genome sequence and feature analysis of Thermococcus onnurineus NA1 isolated from a deep-sea hydrothermal vent area, which reveal clues to its physiology. Based on results of genomic analysis, T. onnurineus NA1 possesses the metabolic pathways for organotrophic growth on peptides, amino acids, or sugars. More interesting was the discovery that the genome encoded unique proteins that are involved in carboxydotrophy to generate energy by oxidation of CO to CO2, thereby providing a mechanistic basis for growth with CO as substrate. This lithotrophic feature in combination with carbon fixation via RuBisCO introduces a new strategy with a complementing energy supply for T. onnurineus NA1 potentially allowing it to cope with nutrient stress in the surrounding of hydrothermal vents, providing the first genomic evidence for the carboxydotrophy in Thermococcus.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29827
Bibliographic Citation
Extremophile 2008, pp.134, 2008
Publisher
Internation Society of Extremophile
Type
Conference
Language
English
Publisher
Internation Society of Extremophile
Related Researcher
Research Interests

marine biotechnology,molecular microbiology,해양생명공학,분자미생물학

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