Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage

Title
Protective effect of fucoxanthin isolated from Sargassum siliquastrum on UV-B induced cell damage
Author(s)
허수진; 전유진; 박흥식; 최영웅; Abu Affan; 이대원; 강도형
KIOST Author(s)
Heo, Soo Jin(허수진)Park, Heung-Sik(박흥식)Lee, Dae Won(이대원)Kang, Do-Hyung(강도형)
Publication Year
2009-04-06
Abstract
Fucoxanthin is a carotenoid isolated from Sargassum siliquastrum and is considered to be one of major active compound of marine algae. In this study, we investigated and confirmed the protective effect of fucoxanthin on UV-B induced cell injury in human fibroblast via 2’,7’-dichlorodihydrofluorescein diace-tate (DCFH-DA), 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT), and comet assays. Intracellular ROS generated by exposure to UV-B radiation, which was significantly decreased by addition with various concentrations of fucoxanthin. Cell survival rate was increased with fucoxanthin pre-treated cells, which was reached around 81.47% at 100 μM, and the inhibitory effect of cell damage exhibited dose-dependent manner. Moreover, fucoxanthin having protective properties was demonstrated via Hoechst 33342/PI staining. Hence, on the basis of the above-mentioned studies, fucoxanthin has the ability to protect against oxidative stress induced by UV-B radiation and which might be applied to antioxidant and cosmeceutical industries.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/29581
Bibliographic Citation
BIT\\\\\\\\, pp.310, 2009
Publisher
World Congree of Industrial Biotechnology
Type
Conference
Language
English
Publisher
World Congree of Industrial Biotechnology
Related Researcher
Research Interests

Marine ecology,Marine biology,Marine living resources,해양생태,해양생물 생리,해양생물자원

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