Gageostatins A-C, Antimicrobial Linear Lipopeptides from a Marine Bacillus subtilis SCIE SCOPUS

DC Field Value Language
dc.contributor.author Tareq, Fakir Shahidullah -
dc.contributor.author Lee, Min Ah -
dc.contributor.author Lee, Hyi-Seung -
dc.contributor.author Lee, Jong-Seok -
dc.contributor.author Lee, Yeon-Ju -
dc.contributor.author Shin, Hee Jae -
dc.date.accessioned 2020-04-20T04:55:12Z -
dc.date.available 2020-04-20T04:55:12Z -
dc.date.created 2020-01-28 -
dc.date.issued 2014-02 -
dc.identifier.issn 1660-3397 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/2906 -
dc.description.abstract Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3--hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtilis. Their structures were elucidated by analyzing a combination of extensive 1D, 2D NMR spectroscopic data and high resolution ESIMS data. Fatty acids, namely 3--hydroxy-11-methyltridecanoic and 3--hydroxy-9,11-dimethyltridecanoic acids were characterized in lipopeptides 1 and 2, respectively, whereas an unsaturated fatty acid (E)-7,9-dimethylundec-2-enoic acid was assigned in 3. The 3R configuration of the stereocenter of 3--hydroxy fatty acids in 1 and 2 was established by Mosher's MTPA method. The absolute stereochemistry of amino acid residues in 1-3 was ascertained by acid hydrolysis followed by Marfey's derivatization studies. Gageostatins 1-3 exhibited good antifungal activities with MICs values of 4-32 mu g/mL when tested against pathogenic fungi (R. solani, B. cinerea and C. acutatum) and moderate antibacterial activity against bacteria (B. subtilis, S. aeureus, S. typhi and P. aeruginosa) with MICs values of 8-64 mu g/mL. Futhermore, gageostatins 1-3 displayed cytotoxicity against six human cancer cell lines with GI(50) values of 4.6-19.6 mu g/mL. It is also noteworthy that mixed compounds 1+2 displayed better antifungal and cytotoxic activities than individuals. -
dc.description.uri 1 -
dc.language English -
dc.publisher MDPI AG -
dc.subject COMPLETE GENOME SEQUENCE -
dc.subject BACTERIUM -
dc.subject PEPTIDES -
dc.subject ANTIBACTERIAL -
dc.subject PURIFICATION -
dc.subject METABOLITES -
dc.subject INHIBITOR -
dc.subject INDUCTION -
dc.subject APOPTOSIS -
dc.subject SURFACTIN -
dc.title Gageostatins A-C, Antimicrobial Linear Lipopeptides from a Marine Bacillus subtilis -
dc.type Article -
dc.citation.endPage 885 -
dc.citation.startPage 871 -
dc.citation.title MARINE DRUGS -
dc.citation.volume 12 -
dc.citation.number 2 -
dc.contributor.alternativeName TAREQ -
dc.contributor.alternativeName 이민아 -
dc.contributor.alternativeName 이희승 -
dc.contributor.alternativeName 이종석 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 신희재 -
dc.identifier.bibliographicCitation MARINE DRUGS, v.12, no.2, pp.871 - 885 -
dc.identifier.doi 10.3390/md12020871 -
dc.identifier.scopusid 2-s2.0-84896704517 -
dc.identifier.wosid 000335745100015 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus COMPLETE GENOME SEQUENCE -
dc.subject.keywordPlus BACTERIUM -
dc.subject.keywordPlus PEPTIDES -
dc.subject.keywordPlus ANTIBACTERIAL -
dc.subject.keywordPlus PURIFICATION -
dc.subject.keywordPlus METABOLITES -
dc.subject.keywordPlus INHIBITOR -
dc.subject.keywordPlus INDUCTION -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordPlus SURFACTIN -
dc.subject.keywordAuthor Bacillus subtilis -
dc.subject.keywordAuthor lipopeptides -
dc.subject.keywordAuthor antimicrobial activity -
dc.subject.keywordAuthor cytotoxicity -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
Appears in Collections:
Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 1. Journal Articles
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