EFFECTS OF 4-NONYLPHENOL EXPOSURE ON VITELLOGENESIS RESPONS IN THREE FISH SPECIES

Title
EFFECTS OF 4-NONYLPHENOL EXPOSURE ON VITELLOGENESIS RESPONS IN THREE FISH SPECIES
Author(s)
정지현; 배선혜; 백경란; 김명희; 이재용; 심원준; 한창희
KIOST Author(s)
Jung, Jee Hyun(정지현)Shim, Won Joon(심원준)
Publication Year
2010-06-02
Abstract
Dose-response effects of the estrogenic compound 4-nonylphenol (4-NP) on vitellogenesis were investigated in juvenile olive flounder (Paralichthys olivaceus), rockfish (Sebastes schlegeli,) and red seabream (Pagrus major). They were continuously exposed to 4-NP at concentrations of 10, 50 and 100 즗g/ L for 7 days using an intermittent flow-through dosing system. Plasma vitellogenin (VTG) and hepatic VTG mRNA were determined in groups of fish sampled during exposure. In two species (P. olivaceus and S. schlegeli), VTG mRNA apparently increased in four day after exposure. VTG proteins in P. olivaceus and P. major were induced at 50 ug/L from the fourth day of exposure, and S. schlegeli was induced at 20 ug/L. Plasma concentrations of testosterone in the exposure groups were not significantly different from those in the control group. However, plasma estradiol-17꺬 concentrations of the females increased in P. olivaceus and S. schlegeli after exposure. Our results suggest that 4-NP may disrupt the vitellogenesis system of immature fish by acting directly on vitellogenesis and steroidogenesis. Immature S. schlegeli exposed to 4-NP were more sensitive than P. olivaceus and P. major. This supports the hypothesis that fish show inter-species differences in binding affinities to estrogen receptor in vivo because of amino acid variation at the binding site.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/28955
Bibliographic Citation
6th International conference on marine pollution and ecotoxicology, pp.125, 2010
Publisher
City University of Hong Kong
Type
Conference
Language
English
Publisher
City University of Hong Kong
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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