Isolation and identification of novel compound, 2,7?phloroglucinol-6,6?bieckol from brown algae, Ecklonia cava and its antioxidant effect

DC Field Value Language
dc.contributor.author Sung-Myung Kang -
dc.contributor.author 허수진 -
dc.contributor.author Kil-Nam Kim -
dc.contributor.author Seung-Hong Lee -
dc.contributor.author Seok-Chun Ko -
dc.contributor.author You-Jin Jeon -
dc.date.accessioned 2020-07-16T18:48:06Z -
dc.date.available 2020-07-16T18:48:06Z -
dc.date.created 2020-02-11 -
dc.date.issued 2010-11-18 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/28520 -
dc.description.abstract Ecklonia cava has been regarded as a useful material in the prevention or treatment of several human diseases in Jeju Island, Korea. In this study, we investigated its antioxidant activity, and isolated a novel antioxidative compound, which was identified as 2,7?phloroglucinol-6,6?bieckol (PHB) on the basis of LC/MS, as well as 1H and 13C NMR spectroscopy results. The antioxidant activities of PHB were evaluated via several in vitro assays, such as radical scavenging activities (DPPH, alkyl, hydroxyl, and superoxide) using ESR spectrometry, intracellular ROS scavenging activity, and DNA damage assays. PHB evidenced profound scavenging activities on DPPH, alkyl, hydroxyl, and superoxide radicals (IC50; 0.51, 2.07, 75.64 and 57.19 ? for DPPH, alkyl, hydroxyl and superoxide radical, respectively). The antioxidant activities of PHB were higher than that of ascorbic acid. Furthermore, PHB effectively inhibited H2O2-induced DNA damage. The results of this study indicate that PHB may prove useful as a novel natural marine antioxidant. -
dc.description.uri 1 -
dc.language English -
dc.publisher Korean Society of Marine Biotechnology -
dc.relation.isPartOf The 6th KSMB Annual Meeting and International Mini-symposium -
dc.title Isolation and identification of novel compound, 2,7?phloroglucinol-6,6?bieckol from brown algae, Ecklonia cava and its antioxidant effect -
dc.type Conference -
dc.citation.endPage 58 -
dc.citation.startPage 58 -
dc.citation.title The 6th KSMB Annual Meeting and International Mini-symposium -
dc.contributor.alternativeName 허수진 -
dc.identifier.bibliographicCitation The 6th KSMB Annual Meeting and International Mini-symposium, pp.58 -
dc.description.journalClass 1 -
Appears in Collections:
Jeju Research Institute > Jeju Bio Research Center > 2. Conference Papers
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