Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp Associated with the Marine Starfish Acanthaster planci
SCIE
SCOPUS
Cited 28 time in
WEB OF SCIENCE
Cited 33 time in
Scopus
-
Title
- Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp Associated with the Marine Starfish Acanthaster planci
-
Author(s)
- Shin, Hee Jae; Lee, Hwa-Sun; Lee, Jong Seok; Shin, Junho; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Yun, Jieun; Kang, Jong Soon
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hwa Sun(이화선); Lee, Jong Seok(이종석); Lee, Min Ah(이민아); Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주)
-
Alternative Author(s)
- 신희재; 이화선; 이종석; 신준호; 이민아; 이희승; 이연주
-
Publication Year
- 2014-06
-
Abstract
- Two new alpha-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI(50) values of 1.10-26.12 mu g/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
-
ISSN
- 1660-3397
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2811
-
DOI
- 10.3390/md12063283
-
Bibliographic Citation
- MARINE DRUGS, v.12, no.6, pp.3283 - 3291, 2014
-
Publisher
- MDPI AG
-
Subject
- ALPHA-PYRONE DERIVATIVES; PROTEASE INHIBITORS; FUNGUS
-
Keywords
- Streptomyces sp.; violapyrones; anti-cancer activity; alpha-pyrones; starfish
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.