Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp Associated with the Marine Starfish Acanthaster planci SCIE SCOPUS

Cited 28 time in WEB OF SCIENCE Cited 30 time in Scopus
Title
Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp Associated with the Marine Starfish Acanthaster planci
Author(s)
Shin, Hee Jae; Lee, Hwa-Sun; Lee, Jong Seok; Shin, Junho; Lee, Min Ah; Lee, Hyi-Seung; Lee, Yeon-Ju; Yun, Jieun; Kang, Jong Soon
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hwa Sun(이화선)Lee, Jong Seok(이종석)Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)
Alternative Author(s)
신희재; 이화선; 이종석; 신준호; 이민아; 이희승; 이연주
Publication Year
2014-06
Abstract
Two new alpha-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (1-4) exhibited cytotoxicity against 10 human cancer cell lines with GI(50) values of 1.10-26.12 mu g/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2811
DOI
10.3390/md12063283
Bibliographic Citation
MARINE DRUGS, v.12, no.6, pp.3283 - 3291, 2014
Publisher
MDPI AG
Subject
ALPHA-PYRONE DERIVATIVES; PROTEASE INHIBITORS; FUNGUS
Keywords
Streptomyces sp.; violapyrones; anti-cancer activity; alpha-pyrones; starfish
Type
Article
Language
English
Document Type
Article
Publisher
MDPI AG
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