Suvanine Sesterterpenes and Deacyl Irciniasulfonic Acids from a Tropical Coscinoderma sp Sponge SCIE SCOPUS

Cited 16 time in WEB OF SCIENCE Cited 17 time in Scopus
Title
Suvanine Sesterterpenes and Deacyl Irciniasulfonic Acids from a Tropical Coscinoderma sp Sponge
Author(s)
Kim, Chang-Kwon; Song, Inn-Hye; Park, Ha Young; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Alternative Author(s)
이연주; 이희승
Publication Year
2014-06
Abstract
The suvanines, a new suvanine salt, five new (2, 4-8) and two known sesterterpenes from the same structural class, and two new modified lipids (9 and 10) were isolated from a Coscinoderma sp. sponge collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic and chemical analyses, a new suvanine salt was determined to be the suvanine N,N-dimethy1-1,3-dimethylherbipoline salt (2) and suvanine-lactam derivatives (4-8) formed by condensations between an oxidized furan moiety and amino adds. The lipid metabolites were found to be new derivatives of the taurine-containing deacyl irciniasulfonic acid class. The suvanines exhibited moderate cytotoxicities against the 1(562 and A549 cell lines, while the new suvanine salt (2) had significant antibacterial activity.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2806
DOI
10.1021/np500156n
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.77, no.6, pp.1396 - 1403, 2014
Publisher
AMER CHEMICAL SOC
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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