Suvanine Sesterterpenes and Deacyl Irciniasulfonic Acids from a Tropical Coscinoderma sp Sponge
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- Suvanine Sesterterpenes and Deacyl Irciniasulfonic Acids from a Tropical Coscinoderma sp Sponge
- Kim, Chang-Kwon; Song, Inn-Hye; Park, Ha Young; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승)
- 이연주; 이희승
- The suvanines, a new suvanine salt, five new (2, 4-8) and two known sesterterpenes from the same structural class, and two new modified lipids (9 and 10) were isolated from a Coscinoderma sp. sponge collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic and chemical analyses, a new suvanine salt was determined to be the suvanine N,N-dimethy1-1,3-dimethylherbipoline salt (2) and suvanine-lactam derivatives (4-8) formed by condensations between an oxidized furan moiety and amino adds. The lipid metabolites were found to be new derivatives of the taurine-containing deacyl irciniasulfonic acid class. The suvanines exhibited moderate cytotoxicities against the 1(562 and A549 cell lines, while the new suvanine salt (2) had significant antibacterial activity.
- JOURNAL OF NATURAL PRODUCTS, v.77, no.6, pp.1396 - 1403, 2014
- AMER CHEMICAL SOC
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