Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice SCIE SCOPUS KCI
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Hong | - |
dc.contributor.author | Kang, Nalae | - |
dc.contributor.author | Kim, Eun-A | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Moon, Sang-Ho | - |
dc.contributor.author | Jeon, Byong-Tae | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.date.accessioned | 2020-04-20T04:40:18Z | - |
dc.date.available | 2020-04-20T04:40:18Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2765 | - |
dc.description.abstract | The antidiabetogenic and antioxidative effects of octaphlorethol A (OPA) isolated from the brown algae Ishige foliacea in streptozotocin (STZ)-induced diabetic mice were analyzed. STZ-induced diabetic mice showed a significant (p < 0.05) increase in blood glucose and lipid peroxidation levels and a significant (p < 0.05) decrease in the plasma insulin level and body weight, compared with controls. Diabetic mice also showed a significant (p < 0.05) decrease in the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-px), compared with controls. Oral treatment with OPA (5 and 10 mg/kg) showed protective effects against all the biochemical parameters studied. OPA-treated mice exhibited suppression of apoptosis, and treatment with OPA was associated with an increase in antiapoptotic BclxL expression and a reduction in pro-apoptotic Bax and cleaved caspase-3 expressions. OPA has antidiabetogenic and antioxidative effects, and potential for use in therapies as both a natural functional food and a pharmaceutical agent. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | INDUCED OXIDATIVE STRESS | - |
dc.subject | BETA-CELL DAMAGE | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | RAT PANCREAS | - |
dc.subject | ACID | - |
dc.subject | HYPERLIPIDEMIA | - |
dc.subject | MECHANISMS | - |
dc.subject | APOPTOSIS | - |
dc.subject | PROTECTS | - |
dc.subject | MELLITUS | - |
dc.title | Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice | - |
dc.type | Article | - |
dc.citation.endPage | 1266 | - |
dc.citation.startPage | 1261 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.23, no.4, pp.1261 - 1266 | - |
dc.identifier.doi | 10.1007/s10068-014-0173-6 | - |
dc.identifier.scopusid | 2-s2.0-84905436290 | - |
dc.identifier.wosid | 000340357200037 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001908390 | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BETA-CELL DAMAGE | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | RAT PANCREAS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | HYPERLIPIDEMIA | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordAuthor | octaphlorethol A | - |
dc.subject.keywordAuthor | antidiabetogenic | - |
dc.subject.keywordAuthor | antioxidative | - |
dc.subject.keywordAuthor | streptozotocin | - |
dc.subject.keywordAuthor | diabetic mice | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |