Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice SCIE SCOPUS KCI

Cited 7 time in WEB OF SCIENCE Cited 6 time in Scopus
Title
Antidiabetogenic and antioxidative effects of octaphlorethol a isolated from the brown algae Ishige foliacea in streptozotocin-induced diabetic mice
Author(s)
Lee, Seung-Hong; Kang, Nalae; Kim, Eun-A; Heo, Soo-Jin; Moon, Sang-Ho; Jeon, Byong-Tae; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2014-08
Abstract
The antidiabetogenic and antioxidative effects of octaphlorethol A (OPA) isolated from the brown algae Ishige foliacea in streptozotocin (STZ)-induced diabetic mice were analyzed. STZ-induced diabetic mice showed a significant (p < 0.05) increase in blood glucose and lipid peroxidation levels and a significant (p < 0.05) decrease in the plasma insulin level and body weight, compared with controls. Diabetic mice also showed a significant (p < 0.05) decrease in the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-px), compared with controls. Oral treatment with OPA (5 and 10 mg/kg) showed protective effects against all the biochemical parameters studied. OPA-treated mice exhibited suppression of apoptosis, and treatment with OPA was associated with an increase in antiapoptotic BclxL expression and a reduction in pro-apoptotic Bax and cleaved caspase-3 expressions. OPA has antidiabetogenic and antioxidative effects, and potential for use in therapies as both a natural functional food and a pharmaceutical agent.
ISSN
1226-7708
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2765
DOI
10.1007/s10068-014-0173-6
Bibliographic Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.23, no.4, pp.1261 - 1266, 2014
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Subject
INDUCED OXIDATIVE STRESS; BETA-CELL DAMAGE; LIPID-PEROXIDATION; RAT PANCREAS; ACID; HYPERLIPIDEMIA; MECHANISMS; APOPTOSIS; PROTECTS; MELLITUS
Keywords
octaphlorethol A; antidiabetogenic; antioxidative; streptozotocin; diabetic mice
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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