Novel Glycolipopeptides from a Marine-Derived Bacterium Bacillus licheniformis

Abstract

Marine microbial natural products continue to represent an important source of novel compounds for the development of new therapeutic agents. To search for new bioactive marine natural products, we have focused considerable attention on the marine microorganisms. From a marine Bacillus strain isolated from a sediment sample collected from Ieodo, Republic of Korea’s southern reef, we could isolate novel bioactive glycolipopeptides. Glycolipids have been identified as membrane receptors of various pathogenic microorganisms, principally bacteria and viruses as well as antineoplastic agents during the past few years. We present here the discovery of novel glycolipopeptides from a marine‐derived Bacillus licheniformis. The isolation, structure determination, and anticancer and antimicrobial activities of the compounds from a marine bacterium will be presented. the marine microorganisms. From a marine Bacillus strain isolated from a sediment sample collected from Ieodo, Republic of Korea’s southern reef, we could isolate novel bioactive glycolipopeptides. Glycolipids have been identified as membrane receptors of various pathogenic microorganisms, principally bacteria and viruses as well as antineoplastic agents during the past few years. We present here the discovery of novel glycolipopeptides from a marine‐derived Bacillus licheniformis. The isolation, structure determination, and anticancer and antimicrobial activities of the compounds from a marine bacterium will be presented.