ANTIMICROBIAL GLYCOLIPOPEPTIDES, IEODOGLUCOMIDES A AND B FROM A MARINE.DERIVED BACTERIUM BACILLUS LICHENIFORMIS

Title
ANTIMICROBIAL GLYCOLIPOPEPTIDES, IEODOGLUCOMIDES A AND B FROM A MARINE.DERIVED BACTERIUM BACILLUS LICHENIFORMIS
Author(s)
TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석; 신희재
KIOST Author(s)
Lee, Min Ah(이민아)Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
TAREQ; 김지혜; 이민아; 이희승; 이연주; 이종석; 신희재
Publication Year
2012-07-05
Abstract
Chemical studies of ethyl acetate extract from a marine bacterium Bacillus licheniformis afforded two unique glycolipopeptides, ieodoglucomides A (1) and B (2) consisting of an amino acid, a new fatty acid, succinic acid and a sugar moiety. The structural characterization of these compounds was performed by spectroscopic evidences. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfeys and Moshers methods and literature reviews. Compounds I and 2 displayed significant in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GIso values of 25.18 and 17.78, microgram/ml respectively.ety.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27615
Bibliographic Citation
International Conference on Mecicinal Chemistry, pp.214, 2012
Publisher
The University of Poitiers
Type
Conference
Language
English
Publisher
The University of Poitiers
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