Acute toxicity of Iranian Heavy crude oil to the Rockfish (Sebastes schlegeli) feeding disrupts the hepatodetoxification and immune systems

Title
Acute toxicity of Iranian Heavy crude oil to the Rockfish (Sebastes schlegeli) feeding disrupts the hepatodetoxification and immune systems
Author(s)
김하나; 채영선; R.Addison; 심원준; 정지현
KIOST Author(s)
Shim, Won Joon(심원준)Jung, Jee Hyun(정지현)
Publication Year
2012-11-12
Abstract
Oil spilled into marine environments induces thehepatodetoxification system and disrupts immune function in fish (Reynaudand Deschaux, 2006). However, the mechanism of toxicity to theimmune system has not been fully investigated. Changes in the immunesystem may affect disease susceptibility in fish (Zelikoff, 1998). In thisstudy, we describe the effects of spilled crude oil from the “Hebei spirit”(Iranian Heavy Crude Oil in gelatine capsules) on juvenile rockfish. Effectson multiple hepatodetoxific enzymes (Cytochrome P4501A and GST) andon the immune responses including interleukin-1beta (IL-1β), granulocytecolony-stimulating factor (G-CSF) and Cathepsin L (Cat. L) were measuredin liver, spleen and kidney. From 12 h after treatment, the oil-fed groups hadslightly higher concentrations of bile fluorescent metabolites and CYP1Aexpression than the control group in liver and spleen. Cat. L and G-CSFmRNA also increased significantly in the early stages of exposure (from 12hto 48h after exposure) but then decreased to the levels in the control group,or lower. Therefore, it is suggested that innate immune response of oil-fedfish induced sensitively at initial stage due to the IHCO exposure but severalimmune-related markers may decd disrupts immune function in fish (Reynaudand Deschaux, 2006). However, the mechanism of toxicity to theimmune system has not been fully investigated. Changes in the immunesystem may affect disease susceptibility in fish (Zelikoff, 1998). In thisstudy, we describe the effects of spilled crude oil from the “Hebei spirit”(Iranian Heavy Crude Oil in gelatine capsules) on juvenile rockfish. Effectson multiple hepatodetoxific enzymes (Cytochrome P4501A and GST) andon the immune responses including interleukin-1beta (IL-1β), granulocytecolony-stimulating factor (G-CSF) and Cathepsin L (Cat. L) were measuredin liver, spleen and kidney. From 12 h after treatment, the oil-fed groups hadslightly higher concentrations of bile fluorescent metabolites and CYP1Aexpression than the control group in liver and spleen. Cat. L and G-CSFmRNA also increased significantly in the early stages of exposure (from 12hto 48h after exposure) but then decreased to the levels in the control group,or lower. Therefore, it is suggested that innate immune response of oil-fedfish induced sensitively at initial stage due to the IHCO exposure but severalimmune-related markers may dec
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/27363
Bibliographic Citation
33차 북미 환경독성화학회(SETAC, Society of Environmental Toxicology & Chemistry), pp.192, 2012
Publisher
33차
Type
Conference
Language
English
Publisher
33차
Related Researcher
Research Interests

Microplastic pollution,Persistent Organic Pollutants,Oil Pollution,미세플라스틱 오염,잔류성 유기오염물질,유류오염

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