Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo SCIE SCOPUS
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- Title
- Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo
- KIOST Author(s)
- Heo, Soo Jin(허수진)
- Alternative Author(s)
- 허수진
- Publication Year
- 2014-09
- Abstract
- We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death. (C) 2014 Elsevier B.V. All rights reserved.
- ISSN
- 1382-6689
- Bibliographic Citation
- ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.38, no.2, pp.607 - 615, 2014
- Publisher
- ELSEVIER
- Subject
- ECKLONIA-CAVA; BROWN ALGA; LIPID-PEROXIDATION; DIABETIC-PATIENTS; CELL-DAMAGE; STRESS; HYPERGLYCEMIA; ZEBRAFISH; COMPOUND; EXTRACT
- Keywords
- High glucose; Octaphlorethol A; Oxidative stress; Zebrafish model; Hyperglycemia
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
