Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo SCIE SCOPUS

Cited 5 time in WEB OF SCIENCE Cited 6 time in Scopus
Title
Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo
Author(s)
Kang, Min-Cheol; Kim, Kil-Nam; Lakmal, H. H. Chaminda; Kim, Eun-A.; Wijesinghe, W. A. J. P.; Yang, Xiudong; Heo, Soo-Jin; Jeon, You-Jin
KIOST Author(s)
Heo, Soo Jin(허수진)
Publication Year
2014-09
Abstract
We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death. (C) 2014 Elsevier B.V. All rights reserved.
ISSN
1382-6689
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2729
DOI
10.1016/j.etap.2014.08.001
Bibliographic Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.38, no.2, pp.607 - 615, 2014
Publisher
ELSEVIER
Subject
ECKLONIA-CAVA; BROWN ALGA; LIPID-PEROXIDATION; DIABETIC-PATIENTS; CELL-DAMAGE; STRESS; HYPERGLYCEMIA; ZEBRAFISH; COMPOUND; EXTRACT
Keywords
High glucose; Octaphlorethol A; Oxidative stress; Zebrafish model; Hyperglycemia
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER
Related Researcher
Research Interests

Marine Biotechnology,Marine Natural Products,Bioactivities,해양생물공학,해양천연물학,생리활성

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