8번째 carboxylesterase family에 속하는 EstU1의 beta-lactamase 활성에 대한 구조기반 연구
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영준 | - |
dc.contributor.author | 정창숙 | - |
dc.contributor.author | 김민규 | - |
dc.contributor.author | 전정호 | - |
dc.contributor.author | 이현숙 | - |
dc.contributor.author | 강성균 | - |
dc.contributor.author | 이정현 | - |
dc.contributor.author | 차선신 | - |
dc.date.accessioned | 2020-07-16T08:31:02Z | - |
dc.date.available | 2020-07-16T08:31:02Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2013-07-23 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/26855 | - |
dc.description.abstract | EstU1 is a remarkable family VIII carboxylesterase in that it exhibits hydrolytic activity towards the amide bond of clinically-used b-lactam antibiotics as well as the ester bond of p-nitrophenyl esters. The crystal structures of EstU1 and the EstU1/cephalothin complex revealed the structural basis for the catalytic feature. Structural and sequential comparison of EstU1 with other family VIII carboxylesterases that cannot cleave clinically-used b-lactam antibiotics provides insights into an operative molecular strategy of family VIII carboxylesterases to extend their substrate spectrum. the EstU1/cephalothin complex revealed the structural basis for the catalytic feature. Structural and sequential comparison of EstU1 with other family VIII carboxylesterases that cannot cleave clinically-used b-lactam antibiotics provides insights into an operative molecular strategy of family VIII carboxylesterases to extend their substrate spectrum. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 한국구조생물학회 | - |
dc.relation.isPartOf | 2013년 한국구조생물학회 연례학술대회 | - |
dc.title | 8번째 carboxylesterase family에 속하는 EstU1의 beta-lactamase 활성에 대한 구조기반 연구 | - |
dc.title.alternative | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 28 | - |
dc.citation.startPage | 28 | - |
dc.citation.title | 2013년 한국구조생물학회 연례학술대회 | - |
dc.contributor.alternativeName | 안영준 | - |
dc.contributor.alternativeName | 정창숙 | - |
dc.contributor.alternativeName | 김민규 | - |
dc.contributor.alternativeName | 이현숙 | - |
dc.contributor.alternativeName | 강성균 | - |
dc.contributor.alternativeName | 이정현 | - |
dc.contributor.alternativeName | 차선신 | - |
dc.identifier.bibliographicCitation | 2013년 한국구조생물학회 연례학술대회, pp.28 | - |
dc.description.journalClass | 2 | - |