8번째 carboxylesterase family에 속하는 EstU1의 beta-lactamase 활성에 대한 구조기반 연구

DC Field Value Language
dc.contributor.author 안영준 -
dc.contributor.author 정창숙 -
dc.contributor.author 김민규 -
dc.contributor.author 전정호 -
dc.contributor.author 이현숙 -
dc.contributor.author 강성균 -
dc.contributor.author 이정현 -
dc.contributor.author 차선신 -
dc.date.accessioned 2020-07-16T08:31:02Z -
dc.date.available 2020-07-16T08:31:02Z -
dc.date.created 2020-02-11 -
dc.date.issued 2013-07-23 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/26855 -
dc.description.abstract EstU1 is a remarkable family VIII carboxylesterase in that it exhibits hydrolytic activity towards the amide bond of clinically-used b-lactam antibiotics as well as the ester bond of p-nitrophenyl esters. The crystal structures of EstU1 and the EstU1/cephalothin complex revealed the structural basis for the catalytic feature. Structural and sequential comparison of EstU1 with other family VIII carboxylesterases that cannot cleave clinically-used b-lactam antibiotics provides insights into an operative molecular strategy of family VIII carboxylesterases to extend their substrate spectrum. the EstU1/cephalothin complex revealed the structural basis for the catalytic feature. Structural and sequential comparison of EstU1 with other family VIII carboxylesterases that cannot cleave clinically-used b-lactam antibiotics provides insights into an operative molecular strategy of family VIII carboxylesterases to extend their substrate spectrum. -
dc.description.uri 2 -
dc.language English -
dc.publisher 한국구조생물학회 -
dc.relation.isPartOf 2013년 한국구조생물학회 연례학술대회 -
dc.title 8번째 carboxylesterase family에 속하는 EstU1의 beta-lactamase 활성에 대한 구조기반 연구 -
dc.title.alternative Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 28 -
dc.citation.startPage 28 -
dc.citation.title 2013년 한국구조생물학회 연례학술대회 -
dc.contributor.alternativeName 안영준 -
dc.contributor.alternativeName 정창숙 -
dc.contributor.alternativeName 김민규 -
dc.contributor.alternativeName 이현숙 -
dc.contributor.alternativeName 강성균 -
dc.contributor.alternativeName 이정현 -
dc.contributor.alternativeName 차선신 -
dc.identifier.bibliographicCitation 2013년 한국구조생물학회 연례학술대회, pp.28 -
dc.description.journalClass 2 -
Appears in Collections:
Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 2. Conference Papers
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse