Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages
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Title
- Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages
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Author(s)
- Ryu, BoMi; Choi, Il-Whan; Qian, Zhong-Ji; Heo, Soo-Jin; Kang, Do-Hyung; Oh, Chulhong; Jeon, You-Jin; Jang, Chul Ho; Park, Won Sun; Kang, Kyong-Hwa; Je, Jae-Young; Kim, Se-Kwon; Kim, Young-Mog; Ko, Seok-Chun; Kim, GeunHyung; Jung, Won-Kyo
- KIOST Author(s)
- Heo, Soo Jin(허수진); Kang, Do Hyung(강도형); Oh, Chul Hong(오철홍)
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Alternative Author(s)
- 허수진; 강도형; 오철홍
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Publication Year
- 2014-12
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Abstract
- Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.
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ISSN
- 1226-2617
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2669
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DOI
- 10.4490/algae.2014.29.4.343
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Bibliographic Citation
- ALGAE, v.29, no.4, pp.343 - 353, 2014
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Publisher
- KOREAN SOC PHYCOLOGY
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Subject
- NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; ACTIVATED PROTEIN-KINASE; SIGNAL-REGULATED KINASE; ANTIOXIDANT ACTIVITY; LAURENCIA-UNDULATA; IN-VITRO; RHODOMELA-CONFERVOIDES; MURINE MACROPHAGES; GENE-EXPRESSION
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Keywords
- Callophyllis japonica; inflammation; macrophages; MAPKs
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Type
- Article
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Language
- English
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Document Type
- Article
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