Fucoxanthin derivatives from Sargassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-kB and MAPKs in human fibrosarcoma cells SCIE SCOPUS KCI
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dc.contributor.author | Van-Tinh Nguyen | - |
dc.contributor.author | Qian, Zhong-Ji | - |
dc.contributor.author | Lee, Bonggi | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Kim, Kil-Nam | - |
dc.contributor.author | Jeon, You-Jin | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Choi, Il-Whan | - |
dc.contributor.author | Jang, Chul Ho | - |
dc.contributor.author | Ko, Seok-Chun | - |
dc.contributor.author | Park, Sun-Joo | - |
dc.contributor.author | Kim, Yong-Tae | - |
dc.contributor.author | Kim, GeunHyung | - |
dc.contributor.author | Lee, Dae-Sung | - |
dc.contributor.author | Yim, Mi-Jin | - |
dc.contributor.author | Je, Jae-Young | - |
dc.contributor.author | Jung, Won-Kyo | - |
dc.date.accessioned | 2020-04-20T04:25:17Z | - |
dc.date.available | 2020-04-20T04:25:17Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1226-2617 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2668 | - |
dc.description.abstract | Fucoxanthin is known to be an effective cell proliferation inhibitor with anti-tumor and anti-angiogenic activities. However, there is a lack of data regarding the biological effects of cis isomers of fucoxanthin. To assess the potential therapeutic properties of 9'-cis-(6'R) fucoxanthin (FcA), and 13-cis and 13'-cis-(6'R) fucoxanthin complex (FcB) isolated from Sarggassum siliquastrum, we investigated their inhibitory effects on matrix metalloproteinases (MMPs) in phorbol 12-myristate 13-acetate (PMA)-induced human fibrosarcoma (HT1080) cells. FcA and FcB reduced MMP-2 and MMP-9 protein and mRNA levels, as well as the migration of these cells, in a dose-dependent manner. Additionally, FcA and FcB increased levels of MMPs inhibition factors such as tissue inhibitor of metalloproteinase-1. FcA and FcB significantly inhibited the transcriptional activity of nuclear factor kappa B (NF-kappa B) and by inhibiting c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. Our results demonstrate that suppression of the NF-kappa B, JNK, and p38 signaling pathways may inhibit PMA-induced MMP-2 and MMP-9 activity. Therefore, FcA and FcB may be useful in noninvasive therapeutic strategies against fibrosarcoma metastasis. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KOREAN SOC PHYCOLOGY | - |
dc.subject | HT1080 CELLS | - |
dc.subject | TUMOR PROGRESSION | - |
dc.subject | ECKLONIA-CAVA | - |
dc.subject | BROWN-ALGAE | - |
dc.subject | IN-VITRO | - |
dc.subject | KAPPA-B | - |
dc.subject | ACTIVATION | - |
dc.subject | MMP-9 | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | EXPRESSION | - |
dc.title | Fucoxanthin derivatives from Sargassum siliquastrum inhibit matrix metalloproteinases by suppressing NF-kB and MAPKs in human fibrosarcoma cells | - |
dc.type | Article | - |
dc.citation.endPage | 366 | - |
dc.citation.startPage | 355 | - |
dc.citation.title | ALGAE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | ALGAE, v.29, no.4, pp.355 - 366 | - |
dc.identifier.doi | 10.4490/algae.2014.29.4.355 | - |
dc.identifier.scopusid | 2-s2.0-84942080356 | - |
dc.identifier.wosid | 000347370200010 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001955811 | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HT1080 CELLS | - |
dc.subject.keywordPlus | TUMOR PROGRESSION | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | BROWN-ALGAE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MMP-9 | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | fucoxanthin | - |
dc.subject.keywordAuthor | human fibrosarcoma cells (HT1080) | - |
dc.subject.keywordAuthor | matrix metalloproteinases (MMPs) | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase (MAPK) | - |
dc.subject.keywordAuthor | nuclear factor-kappaB (NF-kappa B) | - |
dc.subject.keywordAuthor | Sargassum siliquastrum | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |