Osteoclastogenic effect of marine algae in human osteoblast-like MG-63 cells

Title
Osteoclastogenic effect of marine algae in human osteoblast-like MG-63 cells
Author(s)
허수진; 예보람; 장지이; 김민선; 김준성; 정원교; 오철홍; 강도형
KIOST Author(s)
Heo, Soo Jin(허수진)Oh, Chulhong(오철홍)Kang, Do-Hyung(강도형)
Publication Year
2013-11-12
Abstract
Useful secondary metabolites are obtained from marine algae, various species of which are found in Jeju Island, Korea. We aimed to screen marine algae products for their ability to suppress osteoclastogenic factors. Sargachromanol G (SG) which isolated from marine algae has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1β (IL-1β)-induced osteoclastogenic factors (PGE2, COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-κB (NF-κB) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1β-stimulated MG-63 cells. SG dose-dependently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK1/2, p38, and JNK) and NF-κB (p65, p50, and IκB-α). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-κB activation.ich isolated from marine algae has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1β (IL-1β)-induced osteoclastogenic factors (PGE2, COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-κB (NF-κB) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1β-stimulated MG-63 cells. SG dose-dependently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK1/2, p38, and JNK) and NF-κB (p65, p50, and IκB-α). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-κB activation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/26557
Bibliographic Citation
10th International Marine Biotechnology Coference, pp.92, 2013
Publisher
International Marine Biotechnology Conference
Type
Conference
Language
English
Publisher
International Marine Biotechnology Conference
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