Cromene regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells
DC Field | Value | Language |
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dc.contributor.author | 허수진 | - |
dc.contributor.author | 예보람 | - |
dc.contributor.author | 장지이 | - |
dc.contributor.author | 윤원종 | - |
dc.contributor.author | 김길남 | - |
dc.contributor.author | 정원교 | - |
dc.date.accessioned | 2020-07-16T04:32:49Z | - |
dc.date.available | 2020-07-16T04:32:49Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2014-06-20 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/26151 | - |
dc.description.abstract | Bone diseases are characterized by the presence of pro-inflammatory cytokines that regulate bone turnover. The receptor activatorof NF-kB ligand (RANKL) is a soluble osteoblast-derived protein that induces bone resorption through osteoclast differentiation and activation. Sagachromanol G (SG) was isolated from the brown algae Sagassum siliquastrum SG has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1b(IL-1b)-induced osteoclastogenic factors (PGE2, COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-kB (NF-kB) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1b-stimulated MG-63 cells. SG dose-depenently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK 1/2, p38, and JNK) and NF-kB (p65, p50, and IkB-a). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-kB activation. differentiation and activation. Sagachromanol G (SG) was isolated from the brown algae Sagassum siliquastrum SG has anti-osteoclastogenic activity, but its mechanism of action and its active components remain largely unknown. In the present study, we investigated the anti-osteoclastogenic effects of SG on the expression of interleukin-1b(IL-1b)-induced osteoclastogenic factors (PGE2, COX-2, IL-6, OPG, and RANKL) in the human osteoblast cell line MG-63. We also examined the role of the nuclear factor-kB (NF-kB) and the mitogen-activated protein kinase (MAPK) signaling pathways in IL-1b-stimulated MG-63 cells. SG dose-depenently inhibited the production of osteoclastogenic factors in MG-63 cells. SG also inhibited phosphorylation of MAPK (ERK 1/2, p38, and JNK) and NF-kB (p65, p50, and IkB-a). These results suggest that the anti-osteoporotic effect of SG may be because of the modulation of osteoclastogenic factors via suppression of MAPK and NF-kB activation. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | 한국응용생명화학회 | - |
dc.relation.isPartOf | The Korean Society for Applied Biological Chemistry | - |
dc.title | Cromene regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 214 | - |
dc.citation.startPage | 214 | - |
dc.citation.title | The Korean Society for Applied Biological Chemistry | - |
dc.contributor.alternativeName | 허수진 | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 장지이 | - |
dc.identifier.bibliographicCitation | The Korean Society for Applied Biological Chemistry, pp.214 | - |
dc.description.journalClass | 1 | - |