Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice SCIE SCOPUS

Cited 18 time in WEB OF SCIENCE Cited 19 time in Scopus
Title
Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice
Author(s)
Kim, Choong Gon; Kang, Meehye; Lee, Youn-Ho; Min, Won Gi; Kim, Yong Hwan; Kang, Su Jin; Song, Chang Hyun; Park, Soo Jin; Park, Ji Ha; Han, Chang Hyun; Lee, Young Joon; Ku, Sae Kwang
KIOST Author(s)
Kim, Choong Gon(김충곤)Lee, Youn Ho(이윤호)
Publication Year
2015
Abstract
We evaluated the preventive effects of four types of seawater collected in Republic of Korea on hairless mice with 2,4-dinitro-chlorobenzene- (DNCB-) induced allergic/atopic dermatitis (AD). The anti-inflammatory effects were evaluated by measuring tumor necrosis factor-(TNF-) alpha and interleukins (ILs). Glutathione (GSH), malondialdehyde (MDA), superoxide anion, and inducible nitric oxide synthase (iNOS) were measured to evaluate the antioxidant effects. Caspase-3 and poly (ADP-ribose) polymerase (PARP) were observed to measure the antiapoptotic effects; matrix metalloproteinase- (MMP-) 9 levels were also evaluated. Mice with AD had markedly higher clinical skin severity scores and scratching behaviors; higher TNF-alpha and ILs (1 beta, 10, 4, 5, and 13) levels; higher MDA, superoxide anion, caspase-3, PARP, and MMP-9 levels; and greater iNOS activity. However, the severity of AD was significantly decreased by bathing in seawaters, but it did not influence the dermal collagen depositions and skin tissue antioxidant defense systems. These results suggest that bathing in all four seawaters has protective effects against DNCB-induced AD through their favorable systemic and local immunomodulatory effects, active cytoprotective antiapoptotic effects, inhibitory effects of MMP activity and anti-inflammatory and antioxidative effects.
ISSN
1741-427X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2613
DOI
10.1155/2015/179185
Bibliographic Citation
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2015
Publisher
HINDAWI LTD
Subject
AUREOBASIDIUM-PULLULANS SM-2001; SALINE SPA WATER; OXIDATIVE STRESS; NITRIC-OXIDE; CYTOKINE PRODUCTION; THERMAL WATER; NC/NGA MICE; INFLAMMATION; PSORIASIS; SEA
Type
Article
Language
English
Document Type
Article
Publisher
HINDAWI LTD
Related Researcher
Research Interests

Marine Molecular Genetics,Marine Ecology and Evolution,해양분자유전,해양생태및진화

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