Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice
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Title
- Bathing Effects of Various Seawaters on Allergic (Atopic) Dermatitis-Like Skin Lesions Induced by 2,4-Dinitrochlorobenzene in Hairless Mice
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Author(s)
- Kim, Choong Gon; Kang, Meehye; Lee, Youn-Ho; Min, Won Gi; Kim, Yong Hwan; Kang, Su Jin; Song, Chang Hyun; Park, Soo Jin; Park, Ji Ha; Han, Chang Hyun; Lee, Young Joon; Ku, Sae Kwang
- KIOST Author(s)
- Kim, Choong Gon(김충곤); Lee, Youn Ho(이윤호); Min, Won Gi(민원기)
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Alternative Author(s)
- 김충곤; 강미혜; 이윤호; 민원기
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Publication Year
- 2015
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Abstract
- We evaluated the preventive effects of four types of seawater collected in Republic of Korea on hairless mice with 2,4-dinitro-chlorobenzene- (DNCB-) induced allergic/atopic dermatitis (AD). The anti-inflammatory effects were evaluated by measuring tumor necrosis factor-(TNF-) alpha and interleukins (ILs). Glutathione (GSH), malondialdehyde (MDA), superoxide anion, and inducible nitric oxide synthase (iNOS) were measured to evaluate the antioxidant effects. Caspase-3 and poly (ADP-ribose) polymerase (PARP) were observed to measure the antiapoptotic effects; matrix metalloproteinase- (MMP-) 9 levels were also evaluated. Mice with AD had markedly higher clinical skin severity scores and scratching behaviors; higher TNF-alpha and ILs (1 beta, 10, 4, 5, and 13) levels; higher MDA, superoxide anion, caspase-3, PARP, and MMP-9 levels; and greater iNOS activity. However, the severity of AD was significantly decreased by bathing in seawaters, but it did not influence the dermal collagen depositions and skin tissue antioxidant defense systems. These results suggest that bathing in all four seawaters has protective effects against DNCB-induced AD through their favorable systemic and local immunomodulatory effects, active cytoprotective antiapoptotic effects, inhibitory effects of MMP activity and anti-inflammatory and antioxidative effects.
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ISSN
- 1741-427X
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2613
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DOI
- 10.1155/2015/179185
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Bibliographic Citation
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2015, 2015
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Publisher
- HINDAWI LTD
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Type
- Article
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Language
- English
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Document Type
- Article
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