Chromene Inhibits LPS-stimulated Inflammation by the NF-kB and MAPKs Pathways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장지이 | - |
dc.contributor.author | 예보람 | - |
dc.contributor.author | 김민선 | - |
dc.contributor.author | 이아름 | - |
dc.contributor.author | 김길남 | - |
dc.date.accessioned | 2020-07-16T03:52:21Z | - |
dc.date.available | 2020-07-16T03:52:21Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2014-08-25 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/26054 | - |
dc.description.abstract | Cells stimulated by various reactions to produce inflammatory responses can be exacerbated, which can lead to a plethora of diseases or cancer. Chromenes from the Sargassum species are reported to have anti-inflammatory activity therefore, in this study, chromene was identified as a natural effective remedy for inflammation. We isolated a functional algal chromene compound from Sargassum siliquastrum, named sargachromanol D (SD). The anti-inflammatory effect of SD on lipopolysaccharide (LPS)-exposed RAW 264.7 cells was evaluated by measuring cell viability, cytotoxicity, and production of inflammatory mediators and the pro-inflammatory cytokines. SD inhibited production of NO and PGE2 from LPS-induced cells by preventing the expression of iNOS and COX-2 in a concentration-dependent manner. Along with this, levels of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were reduced with increasing concentrations of SD. Moreover, SD inhibited the activation of NF-κB and mitogenactivated protein kinases (MAPKs) pathways in a dose-dependent manner. These results show that SD inhibits LPS-stimulated inflammation by mediation of the NF-κB and MAPKs pathways in macrophages. in this study, chromene was identified as a naturaleffective remedy for inflammation. We isolated a functional algal chromene compound from Sargassum siliquastrum, named sargachromanol D (SD). The anti-inflammatory effect of SD on lipopolysaccharide (LPS)-exposed RAW 264.7 cells was evaluated by measuring cell viability, cytotoxicity, and production of inflammatory mediators and the pro-inflammatory cytokines. SD inhibited production of NO and PGE2 from LPS-induced cells by preventing the expression of iNOS and COX-2 in a concentration-dependent manner. Along with this, levels of the pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were reduced with increasing concentrations of SD. Moreover, SD inhibited the activation of NF-κB and mitogenactivated protein kinases (MAPKs) pathways in a dose-dependent manner. These results show that SD inhibits LPS-stimulated inflammation by mediation of the NF-κB and MAPKs pathways in macrophages. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 한국식품과학회 | - |
dc.relation.isPartOf | 제81차 학술대회 및 정기총회 | - |
dc.title | Chromene Inhibits LPS-stimulated Inflammation by the NF-kB and MAPKs Pathways | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 365 | - |
dc.citation.startPage | 365 | - |
dc.citation.title | 제81차 학술대회 및 정기총회 | - |
dc.contributor.alternativeName | 장지이 | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 김민선 | - |
dc.contributor.alternativeName | 이아름 | - |
dc.identifier.bibliographicCitation | 제81차 학술대회 및 정기총회, pp.365 | - |
dc.description.journalClass | 2 | - |