Biologically-active indole-containing compound-natural products from sponges and their synthetic analogs

DC Field Value Language
dc.contributor.author 이연주 -
dc.date.accessioned 2020-07-16T03:33:13Z -
dc.date.available 2020-07-16T03:33:13Z -
dc.date.created 2020-02-11 -
dc.date.issued 2014-10-16 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/25959 -
dc.description.abstract Guided by the inhibitory activities of indole-containing marine natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.roducts were synthesized. Eight Srt A inhibitors and two ICL inhibitors having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the Srt A inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents. -
dc.description.uri 2 -
dc.language English -
dc.publisher 한국해양바이오학회 -
dc.relation.isPartOf The 10th KSMB Annual Meeting & Symposium -
dc.title Biologically-active indole-containing compound-natural products from sponges and their synthetic analogs -
dc.title.alternative Biologically-active indole-containing compounds-natural products from sponges and their synthetic analogs -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 7 -
dc.citation.startPage 7 -
dc.citation.title The 10th KSMB Annual Meeting & Symposium -
dc.contributor.alternativeName 이연주 -
dc.identifier.bibliographicCitation The 10th KSMB Annual Meeting & Symposium, pp.7 -
dc.description.journalClass 2 -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 2. Conference Papers
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