구조를 기반으로 하는 락타메이즈 저해제 개발

Abstract

The emergence and dissemination of drug-resistant pathogens are great threat to public health in theworld. The expression of beta-lactamases, which inactivate antibiotics, is a prevalent resistancemechanism of bacteria to beta-lactam antibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitortibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitor