구조를 기반으로 하는 락타메이즈 저해제 개발

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dc.contributor.author 차선신 -
dc.date.accessioned 2020-07-16T01:52:47Z -
dc.date.available 2020-07-16T01:52:47Z -
dc.date.created 2020-02-11 -
dc.date.issued 2015-04-16 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/25647 -
dc.description.abstract The emergence and dissemination of drug-resistant pathogens are great threat to public health in theworld. The expression of beta-lactamases, which inactivate antibiotics, is a prevalent resistancemechanism of bacteria to beta-lactam antibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitortibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitor -
dc.description.uri 2 -
dc.language English -
dc.publisher 대한화학회 -
dc.relation.isPartOf 115회 대한 화학회 학술발표회 -
dc.title 구조를 기반으로 하는 락타메이즈 저해제 개발 -
dc.title.alternative Structure-guided discovery of a novel inhibitor against class C betalactamases -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 15 -
dc.citation.startPage 15 -
dc.citation.title 115회 대한 화학회 학술발표회 -
dc.identifier.bibliographicCitation 115회 대한 화학회 학술발표회, pp.15 -
dc.description.journalClass 2 -
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