구조를 기반으로 하는 락타메이즈 저해제 개발

Title
구조를 기반으로 하는 락타메이즈 저해제 개발
Alternative Title
Structure-guided discovery of a novel inhibitor against class C betalactamases
Author(s)
차선신
Publication Year
2015-04-16
Abstract
The emergence and dissemination of drug-resistant pathogens are great threat to public health in theworld. The expression of beta-lactamases, which inactivate antibiotics, is a prevalent resistancemechanism of bacteria to beta-lactam antibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitortibiotics. Therefore, the development of inhibitors against betalactamasesis a challenge to treat drug-resistant pathogens. Recently, a non-beta-lactam inhibitor againstclass C beta-lactamases has been discovered in my lab. The chemical structure of this novel inhibitor isdifferent from those of existing inhibitors. In addition, this inhibitor exhibited an in vivo efficacy withoutside-effects in mouse models. In this talk, I present the molecular features of this inhibitor
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/25647
Bibliographic Citation
115회 대한 화학회 학술발표회, pp.15, 2015
Publisher
대한화학회
Type
Conference
Language
English
Publisher
대한화학회
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