Differential gene expression patterns during embryonic development of sea urchin exposed to triclosan

DC Field Value Language
dc.contributor.author 황진익 -
dc.contributor.author 서승석 -
dc.contributor.author 박미례 -
dc.contributor.author 이택견 -
dc.date.accessioned 2020-07-15T23:53:42Z -
dc.date.available 2020-07-15T23:53:42Z -
dc.date.created 2020-02-11 -
dc.date.issued 2015-09-30 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/25296 -
dc.description.abstract Triclosan (TCS 2,4,4′-trichloro-2′-hydroxydiphenyl ether) is a broad-spectrum antibacterial agent used in common industrial, personal care and household products which are eventually rinsed down the drain and discharged with wastewater effluent. It is therefore commonly found in the aquatic environment, leading to the continual exposure of aquatic organisms to TCS and the accumulation of the antimicrobial and its harmful degradation products in their bodies. Toxic effects of TCS on reproductive and developmental progression of some aquatic organisms have been suggested but the underlying molecular mechanisms have not been defined. We investigated the expression patterns of genes involved in the early development of TCS-treated sea urchin StrongylocentrotusnudususingcDNAmicroarrays. We observed that the predominant consequence of TCS treatment in this model system was the widespread repression of TCS-modulated genes. In particular, empty spiracles homeobox 1 (EMX-1), bone morphogenic protein, and chromosomal binding protein genes showed a significant decrease in expression in response to TCS. These results suggest that TCS can induce abnormal development of sea urchin embryos through the concomitant suppression of a number of genes that are necessary for embryonic differentiation in the blastula stage. Our data provide new insight into the crucial role of genes associated with embryonic development in response to Tffluent. It is therefore commonly found in the aquatic environment, leading to the continual exposure of aquatic organisms to TCS and the accumulation of the antimicrobial and its harmful degradation products in their bodies. Toxic effects of TCS on reproductive and developmental progression of some aquatic organisms have been suggested but the underlying molecular mechanisms have not been defined. We investigated the expression patterns of genes involved in the early development of TCS-treated sea urchin StrongylocentrotusnudususingcDNAmicroarrays. We observed that the predominant consequence of TCS treatment in this model system was the widespread repression of TCS-modulated genes. In particular, empty spiracles homeobox 1 (EMX-1), bone morphogenic protein, and chromosomal binding protein genes showed a significant decrease in expression in response to TCS. These results suggest that TCS can induce abnormal development of sea urchin embryos through the concomitant suppression of a number of genes that are necessary for embryonic differentiation in the blastula stage. Our data provide new insight into the crucial role of genes associated with embryonic development in response to T -
dc.description.uri 2 -
dc.language English -
dc.publisher 분자세포생물학회 -
dc.relation.isPartOf 제 27회 분자세포생물학회 발표 논문집 -
dc.title Differential gene expression patterns during embryonic development of sea urchin exposed to triclosan -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 101 -
dc.citation.startPage 101 -
dc.citation.title 제 27회 분자세포생물학회 발표 논문집 -
dc.identifier.bibliographicCitation 제 27회 분자세포생물학회 발표 논문집, pp.101 -
dc.description.journalClass 2 -
Appears in Collections:
South Sea Research Institute > Risk Assessment Research Center > 2. Conference Papers
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