Acute 4-nonlyphenol toxicity induced metabolic changes in marine medaka fish (Oryzias javanicus)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조예진 | - |
dc.contributor.author | 우선옥 | - |
dc.contributor.author | 염승식 | - |
dc.date.accessioned | 2020-07-15T22:52:48Z | - |
dc.date.available | 2020-07-15T22:52:48Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2015-11-13 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/25054 | - |
dc.description.abstract | The differentially expressed genes in the liver tissue of the marine medaka fish, Oryzias javanicus, were profiled using an oligo-microarray (EnviHaz Fish Array ver. 01) after the fish were exposed to 20  g/L 4-nonylphenol (4-NP) for 12, 24, 48, or 72 h to determine the metabolic and physiological changes with exposure time. The transcriptomic changes were highly dynamic in the 4-NP-exposed fish in that among the 216 differentially expressed genes identified in all four exposed fish groups, 106 genes (49.1%) appeared after a specific exposure time. The differentially expressed genes were used to predict the changes that occurred in the metabolic pathways and processes in response to 4-NP exposure. Many physiological and metabolic changes were detected in the early phase of exposure. Significant vitellogenin expression and an estrogenic stimulus response were observed in the fish exposed to 4-NP for 48 h. These results extend our understanding of the biological responses to environmental chemicals at the molecular level and will allow the toxic effects of environmental chemicals, especially endocrine-disrupting chemicals, to be evaluated. 12, 24, 48, or 72 h to determine the metabolic and physiological changes with exposure time. The transcriptomic changes were highly dynamic in the 4-NP-exposed fish in that among the 216 differentially expressed genes identified in all four exposed fish groups, 106 genes (49.1%) appeared after a specific exposure time. The differentially expressed genes were used to predict the changes that occurred in the metabolic pathways and processes in response to 4-NP exposure. Many physiological and metabolic changes were detected in the early phase of exposure. Significant vitellogenin expression and an estrogenic stimulus response were observed in the fish exposed to 4-NP for 48 h. These results extend our understanding of the biological responses to environmental chemicals at the molecular level and will allow the toxic effects of environmental chemicals, especially endocrine-disrupting chemicals, to be evaluated. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | 대한독성유전단백체 | - |
dc.relation.isPartOf | 대한독성유전단백체 | - |
dc.title | Acute 4-nonlyphenol toxicity induced metabolic changes in marine medaka fish (Oryzias javanicus) | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 154 | - |
dc.citation.startPage | 154 | - |
dc.citation.title | 대한독성유전단백체 | - |
dc.contributor.alternativeName | 조예진 | - |
dc.contributor.alternativeName | 우선옥 | - |
dc.contributor.alternativeName | 염승식 | - |
dc.identifier.bibliographicCitation | 대한독성유전단백체, pp.154 | - |
dc.description.journalClass | 1 | - |