Ieodoglucomide C and Ieodoglycolipid, New Glycolipids from a Marine-Derived Bacterium Bacillus licheniformis 09IDYM23 SCIE SCOPUS

Cited 16 time in WEB OF SCIENCE Cited 20 time in Scopus
Title
Ieodoglucomide C and Ieodoglycolipid, New Glycolipids from a Marine-Derived Bacterium Bacillus licheniformis 09IDYM23
Author(s)
Tareq, Fakir Shahidullah; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Shin, Hee Jae
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
이희승; 이연주; 이종석; 신희재
Publication Year
2015-05
Abstract
Chemical examination of the ethyl acetate extract from the fermentation broth of the marine-derived bacterium Bacillus licheniformis resulted in the isolation of two new glycolipids, ieodoglucomide C (1) and ieodoglycolipid (2). The structural characterization of 1 and 2 was achieved by extensive spectroscopic evidence, including 2D NMR experiments. A combination of chemical derivatization techniques followed by NMR studies, LC-MS data analysis and a literature review was deployed for the establishment of the stereo-configurations of 1 and 2. Compounds 1 and 2 exhibited good antibiotic properties against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Escherichia coli and Pseudomonas aeruginosa with MICs ranging from 0.01 to 0.05 mu M. Furthermore, the antifungal activity of 1 and 2 was evaluated against plant pathogenic fungi Aspergillus niger, Rhizoctonia solani, Botrytis cinerea and Colletotrichum acutatum as well as the human pathogen Candida albicans. Compounds 1 and 2 inhibited the mycelial growth of these pathogens with MIC values of 0.03-0.05 mu M, revealing that these compounds are good candidates for the development of new fungicides.
ISSN
0024-4201
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2500
DOI
10.1007/s11745-015-4014-z
Bibliographic Citation
LIPIDS, v.50, no.5, pp.513 - 519, 2015
Publisher
SPRINGER HEIDELBERG
Subject
GALACTOSYLCERAMIDE KRN7000; GLYCOSIDE ANALOG
Keywords
Bacillus licheniformis; Glycolipopeptide; Monoacyldiglycosylglycerolipid; Stereoconfiguration; Antimicrobial properties
Type
Article
Language
English
Document Type
Article
Publisher
SPRINGER HEIDELBERG
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