Suvanine analogs from a Coscinoderma sp marine sponge and their cytotoxicities against human cancer cell lines
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Title
- Suvanine analogs from a Coscinoderma sp marine sponge and their cytotoxicities against human cancer cell lines
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Author(s)
- Lee, Jeong-Woo; Lee, Hyi-Seung; Shin, Jongheon; Kang, Jong Soon; Yun, Jieun; Shin, Hee Jae; Lee, Jong Seok; Lee, Yeon-Ju
- KIOST Author(s)
- Lee, Hyi Seung(이희승); Shin, Hee Jae(신희재); Lee, Jong Seok(이종석); Lee, Yeon Ju(이연주)
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Alternative Author(s)
- 이정우; 이희승; 신희재; 이종석; 이연주
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Publication Year
- 2015-06
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Abstract
- Nine suvanine analogs including suvanine phenethylammonium salt and two new compounds were isolated from the marine sponge Coscinoderma sp., collected from Chuuk State, Federated States of Micronesia. The structures of the new compounds were elucidated by 2D NMR and HRMS analyses. Suvanine and a new analog exhibited weak but selective cytotoxicity against colon (HCT-15), lung (NCI-H23), stomach (NUGC-3), and prostate (PC-3) cancer cell lines.
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ISSN
- 0253-6269
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2481
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DOI
- 10.1007/s12272-014-0479-1
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Bibliographic Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.38, no.6, pp.1005 - 1010, 2015
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Publisher
- PHARMACEUTICAL SOC KOREA
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Subject
- SESTERTERPENE SULFATES; INHIBITORS; MATHEWSI; IDENTIFICATION; EPCAM
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Keywords
- Sulfated sesterterpenoid; Suvanine; Cytotoxicity; Human cancer cell line; Marine sponge; Coscinoderma
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Type
- Article
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Language
- English
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Document Type
- Article
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