1메카달톤 샤페론의 열린 및 닫힌 형태의 결정 구조
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영준 | - |
dc.contributor.author | 차선신 | - |
dc.date.accessioned | 2020-07-15T20:52:33Z | - |
dc.date.available | 2020-07-15T20:52:33Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2016-07-04 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/24657 | - |
dc.description.abstract | Proteins mediate nearly all the biochemical reactions in cells and thus the proper protein folding is essential for the survival of cells. Accumulation of misfolded and denatured proteins is engaged in the progression of several diseases including neurodegeneration and cancer. Chaperonins (CPNs) play critical roles in proper folding of nascent proteins or in refolding of denature proteins. CPNs are multi-subunit complexes that have a folding chamber, and ATP-hydrolysis allosterically affects the conformation of CPNs to facilitate folding process. In this study, we present the two crystal structures of a chaperonin to depict the molecular mechanism underpinning the mechanical motion of this protein machine.cluding neurodegeneration and cancer. Chaperonins (CPNs) play critical roles in proper folding of nascent proteins or in refolding of denature proteins. CPNs are multi-subunit complexes that have a folding chamber, and ATP-hydrolysis allosterically affects the conformation of CPNs to facilitate folding process. In this study, we present the two crystal structures of a chaperonin to depict the molecular mechanism underpinning the mechanical motion of this protein machine. | - |
dc.description.uri | 2 | - |
dc.language | English | - |
dc.publisher | 한국결정학회 | - |
dc.relation.isPartOf | 한국결정학회 | - |
dc.title | 1메카달톤 샤페론의 열린 및 닫힌 형태의 결정 구조 | - |
dc.title.alternative | Crystal structures of the open and closed states of a ~1 megadalton chaperonin | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 69 | - |
dc.citation.startPage | 69 | - |
dc.citation.title | 한국결정학회 | - |
dc.contributor.alternativeName | 안영준 | - |
dc.identifier.bibliographicCitation | 한국결정학회, pp.69 | - |
dc.description.journalClass | 2 | - |