A Comparative Developmental Toxicity Study on Embryonic Flounder Exposed to Crude Oils of Different Geological Origin

Title
A Comparative Developmental Toxicity Study on Embryonic Flounder Exposed to Crude Oils of Different Geological Origin
Author(s)
정지현; 김문구; 이은희; 최광민; 하성용; 안준건; 임운혁
KIOST Author(s)
Jung, Jee Hyun(정지현)Kim, Moon Koo(김문구)Ha, Sung Yong(하성용)An, Joon Geon(안준건)Yim, Un Hyuk(임운혁)
Alternative Author(s)
정지현; 김문구; 이은희; 하성용; 안준건; 임운혁
Publication Year
2016-11-10
Abstract
Crude oils from different origins have distinct chemical compositions, hence might produce different toxicity. In the study, embryonic flounder were independently exposed to four crude oils, Basrah Light (Iraq), Pyrenees (Australia), Sakhalin Vityaz (Russia) and MFO-380 (processed fuel oil), with oiled gravel effluent. Total PAH concentrations were highest in MFO-380 (82,600 ng/mg), followed by Sakhalin Vityaz (25,600 ng/mg), Basrah Light (13,200 ng/mg), and Pyrenees (2100 ng/mg). Pyrenees was characterized by its relatively higher compositions of three to four ring PAHs, while two ring PAHs (C0 – C3 naphthalenes) highly dominated in Sakhalin Vityaz. MFO-380 and Basrah Light showed similar relative compositions except that Basrah Light had relatively high concentrations of dibenzothiophene and its alkylated homologues. Overall, the two types of crude oil (Basrah Light and MFO-380) produced highly similar gene expression pattern, primarily characterized by the well-known effects on biotransformation, immune response, cardiac function and oogenesis. Responses also included cardiac edema, spinal curvature and tail fin defect. High frequency percentage of cardiotoxicity and the low level of nkx expression were detected in embryonic flounder exposed to pyrenees which have higher composition of three to four rings. The expression level of CYP1A was highest in embryonic flounder exposed to Sakhalin Vityaz and MFO-380.in Vityaz (Russia) and MFO-380 (processed fuel oil), with oiled gravel effluent. Total PAH concentrations were highest in MFO-380 (82,600 ng/mg), followed by Sakhalin Vityaz (25,600 ng/mg), Basrah Light (13,200 ng/mg), and Pyrenees (2100 ng/mg). Pyrenees was characterized by its relatively higher compositions of three to four ring PAHs, while two ring PAHs (C0 – C3 naphthalenes) highly dominated in Sakhalin Vityaz. MFO-380 and Basrah Light showed similar relative compositions except that Basrah Light had relatively high concentrations of dibenzothiophene and its alkylated homologues. Overall, the two types of crude oil (Basrah Light and MFO-380) produced highly similar gene expression pattern, primarily characterized by the well-known effects on biotransformation, immune response, cardiac function and oogenesis. Responses also included cardiac edema, spinal curvature and tail fin defect. High frequency percentage of cardiotoxicity and the low level of nkx expression were detected in embryonic flounder exposed to pyrenees which have higher composition of three to four rings. The expression level of CYP1A was highest in embryonic flounder exposed to Sakhalin Vityaz and MFO-380.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/24335
Bibliographic Citation
SETAC North America 37th Annual Meeting/7th SETAC World Congress, pp.477, 2016
Publisher
Society of Environmental Toxicology and Chemistry
Type
Conference
Language
English
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse