Gageopeptins A and B, new inhibitors of zoospore motility of the phytopathogen Phytophthora capsici from a marine-derived bacterium Bacillus sp 109GGC020
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Title
- Gageopeptins A and B, new inhibitors of zoospore motility of the phytopathogen Phytophthora capsici from a marine-derived bacterium Bacillus sp 109GGC020
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Author(s)
- Tareq, Fakir Shahidullah; Hasan, Choudhury M.; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Surovy, Musrat Zahan; Islam, Md. Tofazzal; Shin, Hee Jae
- KIOST Author(s)
- Lee, Hyi Seung(이희승); Lee, Yeon Ju(이연주); Lee, Jong Seok(이종석); Shin, Hee Jae(신희재)
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Alternative Author(s)
- 이희승; 이연주; 이종석; 신희재
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Publication Year
- 2015-08-15
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Abstract
- The motility of zoospores is critical in the disease cycles of the peronosporomycetes that cause devastating diseases in plants, fishes, vertebrates, and microbes. In the course of screening for secondary metabolites regulating the motility of zoospores of Phytophthora capsici, we discovered two new inhibitors from the ethyl acetate extract of the fermentation broth of a marine-derived strain Bacillus sp. 109GGC020. The structures of these novel metabolites were elucidated as new cyclic lipopeptides and named gageopeptins A (1) and B (2) by spectroscopic analyses including high resolution MS and extensive 1D and 2D NMR. The stereoconfigurations of 1 and 2 were assigned based on the chemical derivatization studies and reviews of the literature data. Although compounds 1 and 2 impaired the motility of zoospores of P. capsici in dose-and time-dependent manners, compound 1 (IC50 = 1 mu g/ml) was an approximately 400-fold stronger motility inhibitor than 2 (IC50 = 400 mu g/ml). Interestingly, the zoospores halted by compound 1 were subsequently lysed at higher concentrations (IC50 = 50 mu g/ml). Compounds 1 and 2 were also tested against some bacteria and fungi by broth dilution assay, and exhibited moderate antibacterial and good antifungal activities. (C) 2015 Elsevier Ltd. All rights reserved.
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ISSN
- 0960-894X
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2431
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DOI
- 10.1016/j.bmcl.2015.05.070
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Bibliographic Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.16, pp.3325 - 3329, 2015
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Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
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Subject
- ANTIBACTERIAL; LIPOPEPTIDES; OIL
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Keywords
- Zoospore motility inhibitors; Marine bacteria; Phytopathogens; Phytophthora capsici; Lytic acitivity
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Type
- Article
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Language
- English
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Document Type
- Article
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