Gageopeptins A and B, new inhibitors of zoospore motility of the phytopathogen Phytophthora capsici from a marine-derived bacterium Bacillus sp 109GGC020 SCIE SCOPUS

Cited 11 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Gageopeptins A and B, new inhibitors of zoospore motility of the phytopathogen Phytophthora capsici from a marine-derived bacterium Bacillus sp 109GGC020
Author(s)
Tareq, Fakir Shahidullah; Hasan, Choudhury M.; Lee, Hyi-Seung; Lee, Yeon-Ju; Lee, Jong Seok; Surovy, Musrat Zahan; Islam, Md. Tofazzal; Shin, Hee Jae
KIOST Author(s)
Lee, Hyi Seung(이희승)Lee, Yeon Ju(이연주)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)
Alternative Author(s)
이희승; 이연주; 이종석; 신희재
Publication Year
2015-08-15
Abstract
The motility of zoospores is critical in the disease cycles of the peronosporomycetes that cause devastating diseases in plants, fishes, vertebrates, and microbes. In the course of screening for secondary metabolites regulating the motility of zoospores of Phytophthora capsici, we discovered two new inhibitors from the ethyl acetate extract of the fermentation broth of a marine-derived strain Bacillus sp. 109GGC020. The structures of these novel metabolites were elucidated as new cyclic lipopeptides and named gageopeptins A (1) and B (2) by spectroscopic analyses including high resolution MS and extensive 1D and 2D NMR. The stereoconfigurations of 1 and 2 were assigned based on the chemical derivatization studies and reviews of the literature data. Although compounds 1 and 2 impaired the motility of zoospores of P. capsici in dose-and time-dependent manners, compound 1 (IC50 = 1 mu g/ml) was an approximately 400-fold stronger motility inhibitor than 2 (IC50 = 400 mu g/ml). Interestingly, the zoospores halted by compound 1 were subsequently lysed at higher concentrations (IC50 = 50 mu g/ml). Compounds 1 and 2 were also tested against some bacteria and fungi by broth dilution assay, and exhibited moderate antibacterial and good antifungal activities. (C) 2015 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2431
DOI
10.1016/j.bmcl.2015.05.070
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.16, pp.3325 - 3329, 2015
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
ANTIBACTERIAL; LIPOPEPTIDES; OIL
Keywords
Zoospore motility inhibitors; Marine bacteria; Phytopathogens; Phytophthora capsici; Lytic acitivity
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse