New agelasine derivatives from the tropical marine sponge Agelas sp.

DC Field Value Language
dc.contributor.author 엄태양 -
dc.contributor.author 신아영 -
dc.contributor.author 김수현 -
dc.contributor.author 이희승 -
dc.date.accessioned 2020-07-15T18:55:57Z -
dc.date.available 2020-07-15T18:55:57Z -
dc.date.created 2020-02-11 -
dc.date.issued 2016-11-24 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/24305 -
dc.description.abstract Marine sponges have been a remarkably rich sources of biologically active and structurally diverse natural products. Genus of Agelas is known to be a prolific source of different classes of compounds. Among them, agelasines are a class of natural purine diterpenes possessing 9-N-methyladeninium compounds.1 These compounds have also been described to exhibit a wide array of related bioactivities such as antibiotic, antifouling, and K-ATPase inhibiting effects.2In the course of our continuing investigate for novel secondary metabolites from marine invertebrate, we encountered the sponge Agelas sp. from Kosrae, Micronesia. Guided by the 1H NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new agelasine derivative, along with five known diterpenes of the agelasine class. The structure of the new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment.atural purine diterpenes possessing 9-N-methyladeninium compounds.1 These compounds have also been described to exhibit a wide array of related bioactivities such as antibiotic, antifouling, and K-ATPase inhibiting effects.2In the course of our continuing investigate for novel secondary metabolites from marine invertebrate, we encountered the sponge Agelas sp. from Kosrae, Micronesia. Guided by the 1H NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new agelasine derivative, along with five known diterpenes of the agelasine class. The structure of the new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment. -
dc.description.uri 2 -
dc.language English -
dc.publisher 한국해양바이오학회 -
dc.relation.isPartOf 한국해양바이오학회 -
dc.title New agelasine derivatives from the tropical marine sponge Agelas sp. -
dc.type Conference -
dc.citation.conferencePlace KO -
dc.citation.endPage 166 -
dc.citation.startPage 166 -
dc.citation.title 한국해양바이오학회 -
dc.identifier.bibliographicCitation 한국해양바이오학회, pp.166 -
dc.description.journalClass 2 -
Appears in Collections:
Jeju Research Institute > Jeju Marine Research Center > 2. Conference Papers
Marine Resources Research Division > Marine Biotechnology Research Center > 2. Conference Papers
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